Introduction The nose has been receiving increased attention as a route for drug delivery. As
the site of deposition constitutes the first point of contact of the body with the drug …

Introduction Intranasal administration is an effective drug delivery routes in modern
pharmaceutics. However, unlike other in vivo biological barriers, the nasal mucosal barrier is …

The objectives of this study were to expand and implement a Computational Fluid Dynamics
(CFD)-Dissolution, Absorption and Clearance (DAC)-Pharmacokinetics (PK) multi-physics …

Abstract Evaluation of the regional intranasal delivery of locally acting drugs in children is
challenging. Anatomical nasal airway replicas potentially can provide a robust pre-clinical …

Chronic and allergic rhinosinusitis impacts approximately 12% of the global population.
Challenges in rhinosinusitis treatment include paranasal sinus inaccessibility and variability …

In vitro nasal models can potentially facilitate development and approval of nasal drug
products. This study aims to evaluate the potential for using regional deposition …

Nasal sprays are typically characterized using in vitro spray metrics such as spray cone
angle and droplet size distribution. It is currently not clear how these in vitro metrics correlate …

Although nasal inhalation products are becoming more and more important for the delivery
of medicines, characterization of these products for quality control and assessment of …

Large intersubject variability in local drug delivery to the target regions in the nose, the
region posterior to the internal nasal valve (INV), was previously demonstrated in vitro by …

In this study, we examined the correlation between anatomical dimensions, spray
administration parameters, pressure drop across 40 pediatric nasal cavities, and in vitro …