A closer look at amyloid ligands, and what they tell us about protein aggregates

TS Chisholm, CA Hunter - Chemical Society Reviews, 2024 - pubs.rsc.org
The accumulation of amyloid fibrils is characteristic of neurodegenerative diseases such as
Alzheimer's disease (AD) and Parkinson's disease. Detecting these fibrils with fluorescent or …

Strategies for measuring concentrations and forms of amyloid-β peptides

H Shen, K Liu, F Kong, M Ren, X Wang… - Biosensors and …, 2024 - Elsevier
Alzheimer's disease (AD) is affecting more and more people worldwide without the effective
treatment, while the existed pathological mechanism has been confirmed barely useful in …

Vanillin benzothiazole derivative reduces cellular reactive oxygen species and detects amyloid fibrillar aggregates in Alzheimer's disease brain

PK Gharai, J Khan, R Mallesh, S Garg… - ACS Chemical …, 2023 - ACS Publications
The misfolding of amyloid beta (Aβ) peptides into Aβ fibrillary aggregates is a major hallmark
of Alzheimer's disease (AD), which responsible for the excess production of hydrogen …

α-synuclein as a promising biomarker for develo** diagnostic tools against neurodegenerative synucleionopathy disorders

G Bagree, O De Silva, PD Liyanage… - TrAC Trends in …, 2023 - Elsevier
Synucleinopathies are multifactorial neurodegenerative disorders marked by the presence
of intracellular deposits of α-synuclein (α-syn) protein. Although significant progress has …

The carbon dots based on Nile red: The preparation and application to probe α-synuclein fibrils

QY Li, LY Ma, L Li, JT Zhang, X Li, Y Zhang… - Sensors and Actuators B …, 2024 - Elsevier
The aggregation of α-synuclein often links to the occurrence and development of
Parkinson's disease (PD). It is crucial to detect the α-synuclein fibril or monitor the …

A review of the current research on in vivo and in vitro detection for alpha-synuclein: A biomarker of Parkinson's disease

R Wang, S Pang, J Li, C Li, J Liu, Y Wang… - Analytical and …, 2023 - Springer
Parkinson's disease is a health-threatening neurodegenerative disease of the elderly with
clinical manifestations of motor and non-motor deficits such as tremor palsy and loss of …

A solvatofluorochromic dye as a fluorescent lifetime-based probe of β-amyloid aggregation

L Espinar-Barranco, JM Paredes, A Orte, L Crovetto… - Dyes and …, 2022 - Elsevier
In Alzheimer's disease (AD), the initial stages of the aggregation process of the β-amyloid
peptide (Aβ) present a particular interest to understand the origin of the development of this …

Microwave-assisted green synthesis and photophysical properties of bis-heterocyclic fluorophores

PA Chaudhran, A Sharma - Journal of Photochemistry and Photobiology A …, 2024 - Elsevier
An approach for the synthesis of benzimidazole linked with imidazopyridine through a
greener and highly efficient method is proposed herein. The approach involves the use of …

[PDF][PDF] A solvatofluorochromic dye as a fluorescent lifetime-based probe of β-amyloid aggregation

L Crovetto González - 2022 - digibug.ugr.es
In Alzheimer's disease (AD), the initial stages of the aggregation process of the β-amyloid
peptide (Aβ) present a particular interest to understand the origin of the development of this …