RAS proteins are binary switches, cycling between ON and OFF states during signal
transduction. These switches are normally tightly controlled, but in RAS-related diseases …

The mevalonate pathway produces isoprenoids that are vital for diverse cellular functions,
ranging from cholesterol synthesis to growth control. Several mechanisms for feedback …

Small GTP-binding proteins (G proteins) exist in eukaryotes from yeast to human and
constitute a superfamily consisting of more than 100 members. This superfamily is …

Proteins that bind and hydrolyse GTP are being discovered at a rapidly increasing rate.
Each of these many GTPases acts as a molecular switch whose'on'and'off states are …

The heterotrimeric guanine nucleotide-binding proteins (G proteins) act as switches that
regulate information processing circuits connecting cell surface receptors to a variety of …

KRAS is the most frequently mutated oncogene in human cancer. In addition to holding this
distinction, unsuccessful attempts to target this protein have led to the characterization of …

The C-terminal CAAX motif of the yeast mating factors is modified by proteolysis to remove
the three terminal amino acids (-AAX) leaving a C-terminal cysteine resi-, due that is …

The C-terminal CAAX motif of fas proteins undergoes a triplet of posttranslational
modifications that are required for membrane association. The CAAX motif lies immediately …

The small GTP-binding protein rab5 was previously localized on early endosomes and on
the cytoplasmic face of the plasma membrane. Using a cell-free assay, we have now tested …

Although the roots of Ras sprouted from the rich history of retrovirus research, it was the
discovery of mutationally activated RAS genes in human cancer in 1982 that stimulated an …