Background Circadian rhythms are fundamental to health and are particularly important for
mental wellbeing. Disrupted rhythms of rest and activity are recognised as risk factors for …

The [A] allele of SNP rs965513 in 9q22 has been consistently shown to be highly associated
with increased papillary thyroid cancer (PTC) risk with an odds ratio of∼ 1.8 as determined …

As the second most common malignant bone tumor in children and adolescents, Ewing
sarcoma is initiated and exacerbated by a chimeric oncoprotein, most commonly, EWS-FLI1 …

Hox homeobox transcription factors drive leukemogenesis efficiently only in the presence of
Meis or Pbx proteins. Here we show that Pbx3 and Meis1 need to dimerize to support Hox …

Mutations in IDH1, IDH2, and TET2 are recurrently observed in myeloid neoplasms. IDH1
and IDH2 encode isocitrate dehydrogenase isoforms, which normally catalyze the …

Deregulation of key regulators of histone modification is important in the initiation and
progression of human leukemia. Acidic leucine-rich nuclear phosphoprotein-32A (ANP32A) …

Mixed lineage leukemia (MLL) fusion proteins directly activate the expression of key
downstream genes such as MEIS1, HOXA9 to drive an aggressive form of human leukemia …

MEIS1 and MEIS2 encode highly conserved homeodomain transcription factors crucial for
developmental processes in a wide range of tissues, including the brain. They can execute …

Background Selecting a parsimonious set of informative genes to build highly generalized
performance classifier is the most important task for the analysis of tumor microarray …

Several lines of evidence indicate that chronic alcohol use disorder leads to increased
susceptibility to several viral and bacterial infections, whereas moderate alcohol …