Recent progress shows that neurons suitable for transplantation can be generated from
stem cells in culture, and that the adult brain produces new neurons from its own stem cells …

Ageing, which all creatures must encounter, is a challenge to every living organism. In the
human body, it is estimated that cell division and metabolism occurs exuberantly until about …

Glial cell line–derived neurotrophic factor (GDNF) is a potent neurotrophic factor with
restorative effects in a wide variety of rodent and primate models of Parkinson disease, but …

Object. Glial cell line-derived neurotrophic factor (GDNF) has demonstrated significant
antiparkinsonian actions in several animal models and in a recent pilot study in England in …

We report the first post-mortem analysis of two patients with Parkinson's disease who
received fetal midbrain transplants as a cell suspension in the striatum, and in one case also …

Severe dyskinesias during the'off'phases (periods of increased Parkinson's disease (PD)
disability) have been observed following intrastriatal transplantation of human embryonic …

In Parkinson's disease, progressive loss of dopaminergic neurons in the substantia nigra
pars compacta (SN) leads to debilitating motor dysfunction. One current therapy aims at …

The clinical studies with intrastriatal transplants of fetal mesencephalic tissue in Parkinson's
disease (PD) patients have provided proof-of-principle for the cell replacement strategy in …

Transplantation of human pluripotent stem cell (hPSC)-derived neurons is a promising
avenue for treating disorders including Parkinson's disease (PD). Precise control over …

Midbrain dopamine (mDA) neurons can be replaced in patients with Parkinson's disease
(PD) in order to provide long-term improvement in motor functions. The limited capacity for …