Despite considerable progress in genome-and proteome-based high-throughput screening
methods and in rational drug design, the increase in approved drugs in the past decade did …

Scalable sequence–function studies have enabled the systematic analysis and cataloging of
hundreds of thousands of coding and noncoding genetic variants in the human genome …

Cellular processes often depend on stable physical associations between proteins. Despite
recent progress, knowledge of the composition of human protein complexes remains limited …

The correlation of phenotypic outcomes with genetic variation and environmental factors is a
core pursuit in biology and biomedicine. Numerous challenges impede our progress: patient …

Intellectual disability (ID) disorders are genetically and phenotypically extremely
heterogeneous. Can this complexity be depicted in a comprehensive way as a means of …

Bridging the gap between genetic variations, environmental determinants, and phenotypic
outcomes is critical for supporting clinical diagnosis and understanding mechanisms of …

Invertebrate model systems are powerful tools for studying human disease owing to their
genetic tractability and ease of screening. We conducted a mosaic genetic screen of lethal …

Network “guilt by association”(GBA) is a proven approach for identifying novel disease
genes based on the observation that similar mutational phenotypes arise from functionally …

Provision of a molecularly confirmed diagnosis in a timely manner for children and adults
with rare genetic diseases shortens their" diagnostic odyssey," improves disease …

Tumor immune escape is an important part of tumorigenesis and development. Tumor cells
can develop a variety of immunosuppressive mechanisms to combat tumor immunity …