Optimizing the outcomes of pancreatic cancer surgery

O Strobel, J Neoptolemos, D Jaeger… - Nature reviews Clinical …, 2019 - nature.com
Pancreatic cancer is likely to become the second most frequent cause of cancer-associated
mortality within the next decade. Surgical resection with adjuvant systemic chemotherapy …

An update on treatment options for pancreatic adenocarcinoma

A Lambert, L Schwarz, I Borbath… - … in medical oncology, 2019 - journals.sagepub.com
Pancreatic cancer is one of the most lethal solid organ tumors. Due to the rising incidence,
late diagnosis, and limited treatment options, it is expected to be the second leading cause …

Robotic versus open partial pancreatoduodenectomy (EUROPA): a randomised controlled stage 2b trial

R Klotz, AL Mihaljevic, Y Kulu, A Sander… - The Lancet Regional …, 2024 - thelancet.com
Background Open partial pancreatoduodenectomy (OPD) represents the current gold
standard of surgical treatment of a wide range of diseases of the pancreatic head but is …

[HTML][HTML] Perioperative or only adjuvant gemcitabine plus nab-paclitaxel for resectable pancreatic cancer (NEONAX)—a randomized phase II trial of the AIO pancreatic …

T Seufferlein, W Uhl, M Kornmann, H Algül, H Friess… - Annals of …, 2023 - Elsevier
Background Data on perioperative chemotherapy in resectable pancreatic ductal
adenocarcinoma (rPDAC) are limited. NEONAX examined perioperative or adjuvant …

Defining and predicting early recurrence in 957 patients with resected pancreatic ductal adenocarcinoma

VP Groot, G Gemenetzis, AB Blair… - Annals of …, 2019 - journals.lww.com
Objectives: To establish an evidence-based cut-off to differentiate between early and late
recurrence and to compare clinicopathologic risk factors between the two groups. Summary …

[HTML][HTML] Targeted delivery of drugs and genes using polymer nanocarriers for cancer therapy

W **a, Z Tao, B Zhu, W Zhang, C Liu, S Chen… - International journal of …, 2021 - mdpi.com
Cancer is one of the primary causes of worldwide human deaths. Most cancer patients
receive chemotherapy and radiotherapy, but these treatments are usually only partially …

Oncological outcome of conversion surgery after preoperative chemotherapy for metastatic pancreatic cancer

T Hank, U Klaiber, U Hinz, D Schütte… - Annals of …, 2023 - journals.lww.com
Objective: To investigate the outcome of conversion surgery in patients with metastatic
pancreatic cancer (mPDAC) and to identify patients who may benefit from this approach …

State-of-the-art and upcoming innovations in pancreatic cancer care: a step forward to precision medicine

T Schepis, SS De Lucia, A Pellegrino, A Del Gaudio… - Cancers, 2023 - mdpi.com
Simple Summary Pancreatic cancer remains a major therapeutic challenge despite medical
advances. The incidence of pancreatic cancer is increasing, and this disease is associated …

The impact of positive resection margins on survival and recurrence following resection and adjuvant chemotherapy for pancreatic ductal adenocarcinoma

P Ghaneh, J Kleeff, CM Halloran, M Raraty… - Annals of …, 2019 - journals.lww.com
Methods: Analyses were carried out to assess the association between clinical
characteristics and margin involvement as well as the effects of individual margin …

Technical advances in surgery for pancreatic cancer

M Schneider, T Hackert, O Strobel… - British Journal of …, 2021 - academic.oup.com
Background Multimodal treatment concepts enhance options for surgery in locally advanced
pancreatic ductal adenocarcinoma (PDAC). This review provides an overview of technical …