This paper discusses the mechanisms of S. aureus drug resistance including:(1)
introduction.(2) resistance to beta-lactam antibiotics, with particular emphasis on the mec …

Seven mobile oxazolidinone resistance genes, including cfr, cfr (B), cfr (C), cfr (D), cfr (E),
optrA, and poxtA, have been identified to date. The cfr genes code for 23S rRNA methylases …

The oxazolidinones (linezolid and tedizolid) are last-resort antimicrobial agents used for the
treatment of severe infections in humans caused by MDR Gram-positive bacteria. They bind …

Antimicrobial agents are used in both veterinary and human medicine. The intensive use of
antimicrobials in animals may promote the fixation of antimicrobial resistance genes in …

In recent years, methicillin-resistant Staphylococcus aureus (MRSA) have become a truly
global challenge. In addition to the long-known healthcare-associated clones, novel strains …

Enterococcus faecalis, Enterococcus faecium and Staphylococcus aureus are both common
commensals and major opportunistic human pathogens. In recent decades, these bacteria …

Linezolid is an oxazolidinone antibiotic in clinical use for the treatment of serious infections
of resistant Gram-positive bacteria. It inhibits protein synthesis by binding to the peptidyl …

Methicillin resistance in staphylococci is mediated by penicillin binding protein 2a (PBP 2a),
encoded by mecA on mobile staphylococcal cassette chromosome mec (SCC mec) …

Pleuromutilins are antibiotics that selectively inhibit bacterial translation and are
semisynthetic derivatives of the naturally occurring tricyclic diterpenoid pleuromutilin, which …

The emergence of the multiresistance gene cfr in staphylococci is of global concern. In
addition to conferring resistance to phenicols, lincosamides, pleuromutilins, streptogramin A …