Dopamine and addiction

RA Wise, MA Robble - Annual review of psychology, 2020 - annualreviews.org
Addiction is commonly identified with habitual nonmedical self-administration of drugs. It is
usually defined by characteristics of intoxication or by characteristics of withdrawal …

Behavioral and neurobiological mechanisms of pavlovian and instrumental extinction learning

ME Bouton, S Maren, GP McNally - Physiological reviews, 2021 - journals.physiology.org
This article reviews the behavioral neuroscience of extinction, the phenomenon in which a
behavior that has been acquired through Pavlovian or instrumental (operant) learning …

Nucleus accumbens medium spiny neurons subtypes signal both reward and aversion

C Soares-Cunha, NAP de Vasconcelos… - Molecular …, 2020 - nature.com
Deficits in decoding rewarding (and aversive) signals are present in several
neuropsychiatric conditions such as depression and addiction, emphasising the importance …

Optogenetic investigation of neural circuits underlying brain disease in animal models

KM Tye, K Deisseroth - Nature Reviews Neuroscience, 2012 - nature.com
Optogenetic tools have provided a new way to establish causal relationships between brain
activity and behaviour in health and disease. Although no animal model captures human …

Multiple reward signals in the brain

W Schultz - Nature reviews neuroscience, 2000 - nature.com
The fundamental biological importance of rewards has created an increasing interest in the
neuronal processing of reward information. The suggestion that the mechanisms underlying …

Neurobehavioural mechanisms of reward and motivation

TW Robbins, BJ Everitt - Current opinion in neurobiology, 1996 - Elsevier
The analysis of the behavioural and neural mechanisms of reinforcement and motivation
has benefited from the recent application of learning theory and better anatomical …

Dopamine neurons and their role in reward mechanisms

W Schultz - Current opinion in neurobiology, 1997 - Elsevier
Information related to rewards is processed by a limited number of brain structures. Recent
studies have demonstrated that dopamine neurons respond to appetitive events, such as …

Cholinergic interneurons control local circuit activity and cocaine conditioning

IB Witten, SC Lin, M Brodsky, R Prakash, I Diester… - science, 2010 - science.org
Cholinergic neurons are widespread, and pharmacological modulation of acetylcholine
receptors affects numerous brain processes, but such modulation entails side effects due to …

Neurobiology of addiction

RA Wise - Current opinion in neurobiology, 1996 - Elsevier
Addictive drugs have habit-forming actions that can be localized to a variety of brain regions.
Recent advances in our understanding of the chemical 'trigger zones' in which individual …

Nucleus accumbens neurons are innately tuned for rewarding and aversive taste stimuli, encode their predictors, and are linked to motor output

MF Roitman, RA Wheeler, RM Carelli - Neuron, 2005 - cell.com
The nucleus accumbens (NAc) is a key component of the brain's reward pathway, yet little is
known of how NAc cells respond to primary rewarding or aversive stimuli. Here, naive rats …