Deazaguanine modifications play multifaceted roles in the molecular biology of DNA and
tRNA, sha** diverse yet essential biological processes, including the nuanced fine-tuning …

Most of the phylogenetic diversity of life is found in bacteria and archaea, and is reflected in
the diverse metabolism and functions of bacterial and archaeal polyamines. The polyamine …

Background Archaea share a similar microbial lifestyle with bacteria, and not surprisingly
then, also exist within matrix-enclosed communities known as biofilms. Advances in biofilm …

The tRNA modification field has a rich literature covering biochemical analysis going back
more than 40 years, but many of the corresponding genes were only identified in the last …

Threonylcarbamoyladenosine (t6 A) is a modified nucleoside universally conserved in t RNA
s in all three kingdoms of life. The recently discovered genes for t6 A synthesis, including tsa …

ABSTRACT tRNAs play a critical role in mRNA decoding, and posttranscriptional
modifications within tRNAs drive decoding efficiency and accuracy. The types and positions …

Diphthamide is a modified histidine residue which is uniquely present in archaeal and
eukaryotic elongation factor 2 (EF-2), an essential GTPase responsible for catalyzing the …

Seven-deazapurine modifications were thought to be highly specific of tRNAs, but have now
been discovered in DNA of phages and of phylogenetically diverse bacteria, illustrating the …

Halohasta litchfieldiae represents∼ 44% and Halorubrum lacusprofundi∼ 10% of the
hypersaline, perennially cold (≥− 20° C) Deep Lake community in Antarctica. We used …

tRNA modifications are important for decoding, translation accuracy, and structural integrity
of tRNAs. Archaeal tRNAs contain at least 47 different tRNA modifications, some of them …