Myeloid-derived suppressor cells: an emerging target for anticancer immunotherapy

Y Wu, M Yi, M Niu, Q Mei, K Wu - Molecular cancer, 2022 - Springer
The clinical responses observed following treatment with immune checkpoint inhibitors
(ICIs) support immunotherapy as a potential anticancer treatment. However, a large …

Understanding the immunosuppressive microenvironment of glioma: mechanistic insights and clinical perspectives

H Lin, C Liu, A Hu, D Zhang, H Yang, Y Mao - Journal of hematology & …, 2024 - Springer
Glioblastoma (GBM), the predominant and primary malignant intracranial tumor, poses a
formidable challenge due to its immunosuppressive microenvironment, thereby confounding …

[PDF][PDF] Emerging immunotherapy for HCC: A guide for hepatologists

F Foerster, SJ Gairing, SI Ilyas, PR Galle - Hepatology, 2022 - Wiley Online Library
HCC is one of the most common cancers worldwide, and the third leading cause of cancer‐
related death globally. HCC comprises nearly 90% of all cases of primary liver cancer …

CD36+ cancer-associated fibroblasts provide immunosuppressive microenvironment for hepatocellular carcinoma via secretion of macrophage migration inhibitory …

GQ Zhu, Z Tang, R Huang, WF Qu, Y Fang, R Yang… - Cell discovery, 2023 - nature.com
Hepatocellular carcinoma (HCC) is an immunotherapy-resistant malignancy characterized
by high cellular heterogeneity. The diversity of cell types and the interplay between tumor …

Immunosuppressive tumor microenvironment and immunotherapy of hepatocellular carcinoma: current status and prospectives

KY Shen, Y Zhu, SZ **e, LX Qin - Journal of Hematology & Oncology, 2024 - Springer
Hepatocellular carcinoma (HCC) is a major health concern worldwide, with limited
therapeutic options and poor prognosis. In recent years, immunotherapies such as immune …

Neutrophils as potential therapeutic targets in hepatocellular carcinoma

D Geh, J Leslie, R Rumney, HL Reeves… - Nature Reviews …, 2022 - nature.com
The success of atezolizumab plus bevacizumab treatment contributed to a shift in systemic
therapies for hepatocellular carcinoma (HCC) towards combinations that include cancer …

Immunobiology and immunotherapy of HCC: spotlight on innate and innate-like immune cells

B Ruf, B Heinrich, TF Greten - Cellular & molecular immunology, 2021 - nature.com
Immune-based therapies such as immune checkpoint inhibitors have revolutionized the
systemic treatment of various cancer types. The therapeutic application of monoclonal …

Targeting immune cells in the tumor microenvironment of HCC: new opportunities and challenges

X Hao, G Sun, Y Zhang, X Kong, D Rong… - Frontiers in cell and …, 2021 - frontiersin.org
Immune associated cells in the microenvironment have a significant impact on the
development and progression of hepatocellular carcinoma (HCC) and have received more …

Metformin treatment rescues CD8+ T-cell response to immune checkpoint inhibitor therapy in mice with NAFLD

S Wabitsch, JD McCallen, O Kamenyeva, B Ruf… - Journal of …, 2022 - Elsevier
Background & Aims Non-alcoholic steatohepatitis (NASH) represents the fastest growing
underlying cause of hepatocellular carcinoma (HCC) and has been shown to impact …

Gut microbiome directs hepatocytes to recruit MDSCs and promote cholangiocarcinoma

Q Zhang, C Ma, Y Duan, B Heinrich, U Rosato… - Cancer …, 2021 - aacrjournals.org
Gut dysbiosis is commonly observed in patients with cirrhosis and chronic gastrointestinal
disorders; however, its effect on antitumor immunity in the liver is largely unknown. Here we …