The current active–latent paradigm of tuberculosis largely neglects the documented
spectrum of disease. Inconsistency with regard to definitions, terminology, and diagnostic …

Tuberculosis remains a global health problem, with an estimated 10.4 million cases and 1.8
million deaths resulting from the disease in 2015. The most lethal and disabling form of …

Background Adjunctive glucocorticoids are widely used to treat human immunodeficiency
virus (HIV)–associated tuberculous meningitis despite limited data supporting their safety …

Background Every year, an estimated one million children and young adolescents become
ill with tuberculosis, and around 226,000 of those children die. Xpert MTB/RIF Ultra (Xpert …

Summary Background WHO recommends Xpert MTB/RIF as initial diagnostic testing for
tuberculous meningitis. However, diagnosis remains difficult, with Xpert sensitivity of about …

Cerebral toxoplasmosis is the most common cause of expansive brain lesions in people
living with HIV/AIDS (PLWHA) and continues to cause high morbidity and mortality. The most …

Xpert MTB/RIF (Cepheid, Sunnyvale, CA, USA) is endorsed for the detection of pulmonary
tuberculosis (TB). We performed a systematic review and meta-analysis to assess the …

We investigated the epidemiology of extrapulmonary tuberculosis (TB) among patients
admitted to Bei**g Chest Hospital, Bei**g, China, during January 2008–December 2017. Of …

Consensus case definitions for childhood tuberculosis have been proposed by an
international expert panel, aiming to standardize the reporting of cases in research focusing …

Purpose: We assessed the performance of metagenomic next-generation sequencing
(mNGS) in the diagnosis of infectious encephalitis and meningitis. Methods: This was a …