Housekee** genes are involved in basic cell maintenance and, therefore, are expected to
maintain constant expression levels in all cells and conditions. Identification of these genes …

Glioblastoma (GBM) is highly invasive and the deadliest brain tumor in adults. It is
characterized by inter-tumor and intra-tumor heterogeneity, short patient survival, and lack of …

Understanding tumor microenvironment (TME) reprogramming in gastric adenocarcinoma
(GAC) progression may uncover novel therapeutic targets. Here, we performed single-cell …

Aryl hydrocarbon receptor (AHR) activation by tryptophan (Trp) catabolites enhances tumor
malignancy and suppresses anti-tumor immunity. The context specificity of AHR target …

It is currently not well known how necroptosis and necroptosis responses manifest in vivo.
Here, we uncovered a molecular switch facilitating reprogramming between two alternative …

Many primary-tumor subregions have low levels of molecular oxygen, termed hypoxia.
Hypoxic tumors are at elevated risk for local failure and distant metastasis, but the molecular …

Cancer immunotherapy based on genetically redirecting T cells has been used successfully
to treat B cell malignancies,–. In this strategy, the T cell genome is modified by integration of …

Molecular profiles of tumors and tumor-associated cells hold great promise as biomarkers of
clinical outcomes. However, existing data sets are fragmented and difficult to analyze …

Motivation Historically, gene expression has been shown to be the most informative data for
drug response prediction. Recent evidence suggests that integrating additional omics can …

Summary N 6-methyladenosine (m 6 A) is an essential internal RNA modification that is
critical for gene expression control in most organisms. Proteins with a YTH domain …