Microbial secondary metabolites (MSMs) have played and continue to play a highly
significant role in the drug discovery and development process. Genetically, MSM chemical …

In natural product research, microbial metabolites have tremendous potential to provide new
therapeutic agents since extremely diverse chemical structures can be found in the nearly …

For years, fungi have served as repositories of bioactive secondary metabolites that form the
backbone of many existing drugs. With the global rise in infections associated with …

The frequent re-isolation of known compounds is one of the major challenges in drug
discovery. Many biosynthetic genes are not expressed under standard culture conditions …

The emerging and reemerging forms of fungal infections encountered in the course of
allogeneic bone marrow transplantations, cancer therapy, and organ transplants have …

Natural products (NPs) are considered as a cornerstone for the generation of bioactive leads
in drug discovery programs. However, one of the major limitations of NP drug discovery …

Among microorganisms, endophytic fungi are the least studied, but they have attracted
attention due to their high biological diversity and ability to produce novel and bioactive …

There is an urgent need for novel antibiotics to combat emerging resistant microbial strains.
One of the most pressing resources is Aspergillus microbial cocultures. The genome of …

Actinomycetes are a rich source of bioactive natural products important for novel drug leads.
Recent genome mining approaches have revealed an enormous number of secondary …

Lichens are synergetic organisms composed of a mycobiont in relationship with one or more
photosynthetic partners (photobiont). These organisms grow on various substrates and …