From the start of a synthetic chemist's training, experiments are conducted based on recipes
from textbooks and manuscripts that achieve clean reaction outcomes, allowing the scientist …

This Review examines parts per million (ppm) palladium concentrations in catalytic cross-
coupling reactions and their relationship with mole percentage (mol%). Most studies in …

Despite the extensive applications, selective and diverse access to N, N′-diarylethane-1, 2-
diamines remains, to date, a challenge. Here, by develo** a bifunctional cobalt single …

Despite the increased use of computational tools to supplement medicinal chemists'
expertise and intuition in drug design, predicting synthetic yields in medicinal chemistry …

Reaction optimization and characterization depend on reliable measures of reaction yield,
often measured by high-performance liquid chromatography (HPLC). Peak areas in HPLC …

Late‐stage diversification of drug molecules is an important strategy in drug discovery that
can be facilitated by reaction screening using high‐throughput experimentation. Here we …

We report a high throughput evaluation of the Mizoroki–Heck reaction of diverse olefin
coupling partners. Comparison of different ligands revealed the 1, 5-diaza-3, 7 …

Automated batch and flow setups are well‐established for high throughput experimentation
in both thermal chemistry and photochemistry. However, the development of automated …

We have developed a deaminative–decarboxylative protocol to form new carbon (sp3)–
carbon (sp3) bonds from activated amines and carboxylic acids. Amines and carboxylic …

We present an automated droplet reactor platform possessing parallel reactor channels and
a scheduling algorithm that orchestrates all of the parallel hardware operations and ensures …