[HTML][HTML] Human placental development and function

T Cindrova-Davies, AN Sferruzzi-Perri - Seminars in cell & developmental …, 2022 - Elsevier
The placenta is a transient fetal organ that plays a critical role in the health and wellbeing of
both the fetus and its mother. Functionally, the placenta sustains the growth of the fetus as it …

Fertile ground: human endometrial programming and lessons in health and disease

J Evans, LA Salamonsen, A Winship… - Nature Reviews …, 2016 - nature.com
The human endometrium is a highly dynamic tissue that is cyclically shed, repaired,
regenerated and remodelled, primarily under the orchestration of oestrogen and …

Trophoblast organoids as a model for maternal–fetal interactions during human placentation

MY Turco, L Gardner, RG Kay, RS Hamilton, M Prater… - Nature, 2018 - nature.com
The placenta is the extraembryonic organ that supports the fetus during intrauterine life.
Although placental dysfunction results in major disorders of pregnancy with immediate and …

Establishment and differentiation of long-term trophoblast organoid cultures from the human placenta

MA Sheridan, RC Fernando, L Gardner… - Nature …, 2020 - nature.com
The human placenta is essential for successful reproduction. There is great variation in the
anatomy and development of the placenta in different species, meaning that animal models …

Endometrial exosomes/microvesicles in the uterine microenvironment: a new paradigm for embryo-endometrial cross talk at implantation

YH Ng, S Rome, A Jalabert, A Forterre, H Singh… - PloS one, 2013 - journals.plos.org
Exosomes are nanoparticles (∼ 100 nm diameter) released from cells, which can transfer
small RNAs and mRNA via the extracellular environment to cells at distant sites. We …

Hsa-miR-30d, secreted by the human endometrium, is taken up by the pre-implantation embryo and might modify its transcriptome

F Vilella, JM Moreno-Moya, N Balaguer… - …, 2015 - journals.biologists.com
During embryo implantation, the blastocyst interacts with and regulates the endometrium,
and endometrial fluid secreted by the endometrial epithelium nurtures the embryo. Here, we …

Fresh versus frozen embryo transfer: backing clinical decisions with scientific and clinical evidence

J Evans, NJ Hannan, TA Edgell… - Human reproduction …, 2014 - academic.oup.com
BACKGROUND Improvements in vitrification now make frozen embryo transfers (FETs) a
viable alternative to fresh embryo transfer, with reports from observational studies and …

hCG: biological functions and clinical applications

C Nwabuobi, S Arlier, F Schatz… - International journal of …, 2017 - mdpi.com
Human chorionic gonadotropin (hCG) is produced primarily by differentiated
syncytiotrophoblasts, and represents a key embryonic signal that is essential for the …

Identifying biomarkers for predicting successful embryo implantation: applying single to multi-OMICs to improve reproductive outcomes

P Hernández-Vargas, M Muñoz… - Human reproduction …, 2020 - academic.oup.com
BACKGROUND Successful embryo implantation is a complex process that requires the
coordination of a series of events, involving both the embryo and the maternal endometrium …

Human placentation from nidation to 5 weeks of gestation. Part I: What do we know about formative placental development following implantation?

JL James, AM Carter, LW Chamley - Placenta, 2012 - Elsevier
The implantation of the blastocyst and early development of the placenta are crucial for the
success of implantation and pregnancy. However, the formative stages of human placental …