Tissue clearing and 3D reconstruction of digitized, serially sectioned slides provide novel insights into pancreatic cancer
Pancreatic cancer is currently the third leading cause of cancer death in the United States.
The clinical hallmarks of this disease include abdominal pain that radiates to the back, the …
The clinical hallmarks of this disease include abdominal pain that radiates to the back, the …
[HTML][HTML] 3-dimensional reconstruction from histopathological sections: a systematic review
While pathological tissue analysis is typically performed on single 2-dimensional (2D)
histological reference slides, 3-dimensional (3D) reconstruction from a sequence of …
histological reference slides, 3-dimensional (3D) reconstruction from a sequence of …
Ex vivo, in situ perfusion protocol for human brain fixation compatible with microscopy, MRI techniques, and anatomical studies
R Insausti, AM Insausti, M Muñoz López… - Frontiers in …, 2023 - frontiersin.org
We present a method for human brain fixation based on simultaneous perfusion of 4%
paraformaldehyde through carotids after a flush with saline. The left carotid cannula is used …
paraformaldehyde through carotids after a flush with saline. The left carotid cannula is used …
[HTML][HTML] A next-generation, histological atlas of the human brain and its application to automated brain MRI segmentation
Magnetic resonance imaging (MRI) is the standard tool to image the human brain in vivo. In
this domain, digital brain atlases are essential for subject-specific segmentation of …
this domain, digital brain atlases are essential for subject-specific segmentation of …
[HTML][HTML] A 3-dimensional histology computer model of malignant melanoma and its implications for digital pathology
A Kurz, D Krahl, H Kutzner, R Barnhill… - European Journal of …, 2023 - Elsevier
Background Historically, cancer diagnoses have been made by pathologists using two-
dimensional histological slides. However, with the advent of digital pathology and artificial …
dimensional histological slides. However, with the advent of digital pathology and artificial …
Automated deep learning segmentation of high-resolution 7 tesla postmortem MRI for quantitative analysis of structure-pathology correlations in neurodegenerative …
Postmortem MRI allows brain anatomy to be examined at high resolution and to link
pathology measures with morphometric measurements. However, automated segmentation …
pathology measures with morphometric measurements. However, automated segmentation …
A deep learning method for automatic evaluation of diagnostic information from multi-stained histopathological images
Manual screening of large-scale histopathological images is an extremely time-consuming,
laborious and subjective procedure. Accurate evaluation of diagnostic information from multi …
laborious and subjective procedure. Accurate evaluation of diagnostic information from multi …
USLR: an open-source tool for unbiased and smooth longitudinal registration of brain MR
We present USLR, a computational framework for longitudinal registration of brain MRI
scans to estimate nonlinear image trajectories that are smooth across time, unbiased to any …
scans to estimate nonlinear image trajectories that are smooth across time, unbiased to any …
[HTML][HTML] High-resolution atlasing and segmentation of the subcortex: Review and perspective on challenges and opportunities created by machine learning
This paper reviews almost three decades of work on atlasing and segmentation methods for
subcortical structures in human brain MRI. In writing this survey, we have three distinct aims …
subcortical structures in human brain MRI. In writing this survey, we have three distinct aims …
Ultrahigh-resolution 7-Tesla anatomic magnetic resonance imaging and diffusion tensor imaging of ex vivo formalin-fixed human brainstem-cerebellum complex
Introduction Brain cross-sectional images, tractography, and segmentation are valuable
resources for neuroanatomical education and research but are also crucial for neurosurgical …
resources for neuroanatomical education and research but are also crucial for neurosurgical …