Residue mutations and their impact on protein structure and function: detecting beneficial and pathogenic changes
The present review focuses on the evolution of proteins and the impact of amino acid
mutations on function from a structural perspective. Proteins evolve under the law of natural …
mutations on function from a structural perspective. Proteins evolve under the law of natural …
Protein disorder—a breakthrough invention of evolution?
A Schlessinger, C Schaefer, E Vicedo… - Current opinion in …, 2011 - Elsevier
As an operational definition, we refer to regions in proteins that do not adopt regular three-
dimensional structures in isolation, as disordered regions. An antipode to disorder would be …
dimensional structures in isolation, as disordered regions. An antipode to disorder would be …
Functional classification of CATH superfamilies: a domain-based approach for protein function annotation
Motivation: Computational approaches that can predict protein functions are essential to
bridge the widening function annotation gap especially since< 1.0% of all proteins in …
bridge the widening function annotation gap especially since< 1.0% of all proteins in …
INGA: protein function prediction combining interaction networks, domain assignments and sequence similarity
Identifying protein functions can be useful for numerous applications in biology. The
prediction of gene ontology (GO) functional terms from sequence remains however a …
prediction of gene ontology (GO) functional terms from sequence remains however a …
Exploring the evolution of novel enzyme functions within structurally defined protein superfamilies
In order to understand the evolution of enzyme reactions and to gain an overview of
biological catalysis we have combined sequence and structural data to generate …
biological catalysis we have combined sequence and structural data to generate …
CATH FunFHMMer web server: protein functional annotations using functional family assignments
The widening function annotation gap in protein databases and the increasing number and
diversity of the proteins being sequenced presents new challenges to protein function …
diversity of the proteins being sequenced presents new challenges to protein function …
Clustering protein functional families at large scale with hierarchical approaches
Proteins, fundamental to cellular activities, reveal their function and evolution through their
structure and sequence. CATH functional families (FunFams) are coherent clusters of …
structure and sequence. CATH functional families (FunFams) are coherent clusters of …
Catalytic foldamers: When the structure guides the function
B Legrand, J Aguesseau-Kondrotas, M Simon… - Catalysts, 2020 - mdpi.com
Enzymes are predominantly proteins able to effectively and selectively catalyze highly
complex biochemical reactions in mild reaction conditions. Nevertheless, they are limited to …
complex biochemical reactions in mild reaction conditions. Nevertheless, they are limited to …
Quantitative In Silico Evaluation of Allergenic Proteins from Anacardium occidentale, Carya illinoinensis, Juglans regia and Pistacia vera and Their Epitopes as …
The aim of the study presented here was to determine if there is a correlation between the
presence of specific protein domains within tree nut allergens or tree nut allergen epitopes …
presence of specific protein domains within tree nut allergens or tree nut allergen epitopes …