Insulin is a polypeptide hormone mainly secreted by β cells in the islets of Langerhans of the
pancreas. The hormone potentially coordinates with glucagon to modulate blood glucose …

The pancreatic β-cell plays a key role in glucose homeostasis by secreting insulin, the only
hormone capable of lowering the blood glucose concentration. Impaired insulin secretion …

Islets of Langerhans are islands of endocrine cells scattered throughout the pancreas. A
number of new studies have pointed to the potential for conversion of non-β islet cells in to …

Pancreatic β cells secrete insulin, the body's only hormone capable of lowering plasma
glucose levels. Impaired or insufficient insulin secretion results in diabetes mellitus. The β …

It is hypothesized that glucokinase (GCK) is the glucose sensor not only for regulation of
insulin release by pancreatic β-cells, but also for the rest of the cells that contribute to …

The pancreatic islet β cell senses circulating levels of calorigenic nutrients to secrete insulin
according to the needs of the organism. Altered insulin secretion is linked to various …

ATP-sensitive potassium channels (KATP channels) link cell metabolism to electrical activity
by controlling the cell membrane potential. They participate in many physiological processes …

Glucagon, secreted by pancreatic islet α cells, is the principal hyperglycemic hormone. In
diabetes, glucagon secretion is not suppressed at high glucose, exacerbating the …

Glucagon, a hormone released from pancreatic α cells, plays a key role in maintaining
proper glucose homeostasis and has been implicated in the pathophysiology of diabetes. In …

Diabetes is a risk factor for heart failure and cardiovascular mortality with specific changes to
myocardial metabolism, energetics, structure, and function. The gradual impairment of …