Recent advances in limb regeneration are revealing the molecular events that integrate
growth control, cell fate programming, and positional information to yield the exquisite …

The axolotl is one of the few tetrapods that are capable of regenerating complicated
biological structures, such as complete limbs, throughout adulthood. Upon injury the axolotl …

Besides cardiomyocytes (CM), the heart contains numerous interstitial cell types which play
key roles in heart repair, regeneration and disease, including fibroblast, vascular and …

INTRODUCTION Axolotls (Ambystoma mexicanum) and other salamanders are the only
tetrapods that can regenerate whole limbs. During this complex process, changes in gene …

Salamanders regenerate appendages via a progenitor pool called the blastema. The
cellular mechanisms underlying regeneration of muscle have been much debated but have …

Regeneration requires both potential and instructions for tissue replacement. In planarians,
pluripotent stem cells have the potential to produce all new tissue. The identities of the cells …

Connective tissues—skeleton, dermis, pericytes, fascia—are a key cell source for
regenerating the patterned skeleton during axolotl appendage regeneration. This complexity …

In salamanders, grafting of a left limb blastema onto a right limb stump yields regeneration of
three limbs, the normal limb and two 'supernumerary'limbs,,,. This experiment and other …

Cardiac regeneration, that is, restoration of the original structure and function in a damaged
heart, differs from tissue repair, in which collagen deposition and scar formation often lead to …

Zebrafish have the remarkable ability to fully regenerate a lost appendage, faithfully
restoring its size, shape and tissue patterning. Studies over the past decades have identified …