Burden of knee osteoarthritis in 204 countries and territories, 1990–2019: results from the global burden of Disease Study 2019

G Yang, J Wang, Y Liu, H Lu, L He… - Arthritis Care & …, 2023 - Wiley Online Library
Objective To report the global, regional, and national estimates of knee osteoarthritis (OA)
burden and associated risk factors (high body mass index [BMI]) by age, sex, and …

Therapeutic Controlled Release Strategies for Human Osteoarthritis

D Wang, W Liu, JK Venkatesan, H Madry… - Advanced …, 2025 - Wiley Online Library
Osteoarthritis is a progressive, irreversible debilitating whole joint disease that affects
millions of people worldwide. Despite the availability of various options (non …

Botulinum toxin A attenuates osteoarthritis development via inhibiting chondrocyte ferroptosis through SLC7Al1/GPX4 axis

L Zeng, Y Liu, Q Wang, H Wan, X Meng, P Tu… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Osteoarthritis (OA) is a prevalent joint degenerative disease, resulting in a significant
societal burden. However, there is currently a lack of effective treatment option available …

Non-weight-bearing exercise attenuates papain-induced knee osteoarthritis in rats via the TLR4/MyD88/NF-κB signaling pathway

K Wang, X Zhang, X Li, D Li, Z Shan, C Yao - Journal of Orthopaedic …, 2023 - Springer
Abstract Background and Aim Knee osteoarthritis (KOA) is characterized by joint wear and
degeneration. Unfortunately, the medical community currently lacks effective treatment …

rAAV TGF-β and FGF-2 overexpression via pNaSS-Grafted PCL films stimulates the reparative activities of human ACL fibroblasts

M Amini, JK Venkatesan, TN Nguyen, W Liu… - International Journal of …, 2023 - mdpi.com
Lesions in the human anterior cruciate ligament (ACL) are frequent, unsolved clinical issues
due to the limited self-healing ability of the ACL and lack of treatments supporting full …

Commitment of human mesenchymal stromal cells towards ACL fibroblast differentiation upon rAAV‐mediated FGF‐2 and TGF‐β overexpression using pNaSS …

M Stehle, M Amini, JK Venkatesan… - Biotechnology and …, 2024 - Wiley Online Library
Despite various clinical options, human anterior cruciate ligament (ACL) lesions do not fully
heal. Biomaterial‐guided gene therapy using recombinant adeno‐associated virus (rAAV) …

[HTML][HTML] Demographic and Injury Characteristics as Potential Risk Factors for Anterior Cruciate Ligament Injuries: A Multicentric Cross-Sectional Study

M Motififard, H Akbari Aghdam, H Ravanbod… - Journal of Clinical …, 2024 - mdpi.com
Background: Anterior cruciate ligament (ACL) injuries are prevalent and can have
debilitating consequences, with various factors potentially influencing their occurrence. This …

[HTML][HTML] Benzophenone-3 exposure induced apoptosis via impairing mitochondrial function in human chondrocytes

Y Yang, R Gao, Z Zhu, W **ao, J Wang, W Zhao… - … and Environmental Safety, 2024 - Elsevier
Osteoarthritis (OA) is a chronic joint disease affecting millions of adults worldwide,
characterized by degeneration of articular cartilage. Many environmental risk factors …

Exploring the Analgesic Effect of Acupuncture on Knee Osteoarthritis Based on MLT/cAMP/PKA/CREB Signaling Pathway

C Zhang, M Yu, L Zhang, X Zhou, J Han… - Journal of …, 2025 - Taylor & Francis
Background Acupuncture is an effective treatment for knee osteoarthritis (KOA), reducing
pain and improving function. While melatonin (MLT) has notable pain relief benefits, the …

Effects of Leukocyte-rich platelet-rich plasma and Leukocyte-poor platelet-rich plasma on cartilage in a rabbit osteoarthritis model

K Zhang, C Zhang, Q Ren, D Wang, L Sun… - Cellular and Molecular …, 2024 - cellmolbiol.org
Osteoarthritis is a prevalent chronic disease. One of its primary pathological processes
involves the degeneration of articular cartilage. Platelet-rich plasma (PRP) contains …