How the immune system shapes atherosclerosis: roles of innate and adaptive immunity

P Roy, M Orecchioni, K Ley - Nature Reviews Immunology, 2022 - nature.com
Atherosclerosis is the root cause of many cardiovascular diseases. Extensive research in
preclinical models and emerging evidence in humans have established the crucial roles of …

Dendritic cell migration in inflammation and immunity

J Liu, X Zhang, Y Cheng, X Cao - Cellular & molecular immunology, 2021 - nature.com
Dendritic cells (DCs) are the key link between innate immunity and adaptive immunity and
play crucial roles in both the promotion of immune defense and the maintenance of immune …

YTHDF2 orchestrates tumor-associated macrophage reprogramming and controls antitumor immunity through CD8+ T cells

S Ma, B Sun, S Duan, J Han, T Barr, J Zhang… - Nature …, 2023 - nature.com
Despite tumor-associated macrophages (TAMs) playing a key role in sha** the tumor
microenvironment (TME), the mechanisms by which TAMs influence the TME and contribute …

[HTML][HTML] Type I interferon activates MHC class I-dressed CD11b+ conventional dendritic cells to promote protective anti-tumor CD8+ T cell immunity

E Duong, TB Fessenden, E Lutz, T Dinter, L Yim, S Blatt… - Immunity, 2022 - cell.com
Tumor-infiltrating dendritic cells (DCs) assume varied functional states that impact anti-tumor
immunity. To delineate the DC states associated with productive anti-tumor T cell immunity …

Designing cancer immunotherapies that engage T cells and NK cells

O Kyrysyuk, KW Wucherpfennig - Annual review of immunology, 2023 - annualreviews.org
T cells and natural killer (NK) cells have complementary roles in tumor immunity, and dual T
cell and NK cell attack thus offers opportunities to deepen the impact of immunotherapy …

Dendritic cell regulation of T helper cells

X Yin, S Chen, SC Eisenbarth - Annual review of immunology, 2021 - annualreviews.org
As the professional antigen-presenting cells of the immune system, dendritic cells (DCs)
sense the microenvironment and shape the ensuing adaptive immune response. DCs can …

The dynamics of the skin's immune system

AV Nguyen, AM Soulika - International journal of molecular sciences, 2019 - mdpi.com
The skin is a complex organ that has devised numerous strategies, such as physical,
chemical, and microbiological barriers, to protect the host from external insults. In addition …

Dendritic cells and their role in immunotherapy

A Gardner, Á de Mingo Pulido, B Ruffell - Frontiers in immunology, 2020 - frontiersin.org
Despite significant advances in the field of cancer immunotherapy, the majority of patients
still do not benefit from treatment and must rely on traditional therapies. Dendritic cells have …

Dendritic cells in cancer immunology

TL Murphy, KM Murphy - Cellular & molecular immunology, 2022 - nature.com
The clinical success of immune checkpoint therapy (ICT) has produced explosive growth in
tumor immunology research because ICT was discovered through basic studies of immune …

PD-L1 expression by dendritic cells is a key regulator of T-cell immunity in cancer

SA Oh, DC Wu, J Cheung, A Navarro, H **ong… - Nature Cancer, 2020 - nature.com
Inhibiting the programmed death-1 (PD-1) pathway is one of the most effective approaches
to cancer immunotherapy, but its mechanistic basis remains incompletely understood …