Lost in translation: the valley of death across preclinical and clinical divide–identification of problems and overcoming obstacles
AA Seyhan - Translational Medicine Communications, 2019 - Springer
A rift that has opened up between basic research (bench) and clinical research and patients
(bed) who need their new treatments, diagnostics and prevention, and this rift is widening …
(bed) who need their new treatments, diagnostics and prevention, and this rift is widening …
Animal to human translation: a systematic sco** review of reported concordance rates
CHC Leenaars, C Kouwenaar, FR Stafleu… - Journal of translational …, 2019 - Springer
Background Drug development is currently hampered by high attrition rates; many
developed treatments fail during clinical testing. Part of the attrition may be due to low …
developed treatments fail during clinical testing. Part of the attrition may be due to low …
Nanoparticulation of prodrug into medicines for cancer therapy
Y Zhang, H Cui, R Zhang, H Zhang… - Advanced …, 2021 - Wiley Online Library
This article provides a broad spectrum about the nanoprodrug fabrication advances co‐
driven by prodrug and nanotechnology development to potentiate cancer treatment. The …
driven by prodrug and nanotechnology development to potentiate cancer treatment. The …
Microfluidic-assisted fabrication of carriers for controlled drug delivery
The microfluidic technique has brought unique opportunities toward the full control over the
production processes for drug delivery carriers, owing to the miniaturisation of the fluidic …
production processes for drug delivery carriers, owing to the miniaturisation of the fluidic …
[LIVRE][B] Interdisciplinarity and wellbeing: A critical realist general theory of interdisciplinarity
In this book, the authors provide a much-needed general theory of interdisciplinarity and
relate it to health/wellbeing research and professional practice. In so doing they make it …
relate it to health/wellbeing research and professional practice. In so doing they make it …
[HTML][HTML] Sustained and targeted delivery of hydrophilic drug compounds: A review of existing and novel technologies from bench to bedside
The sustained and/or targeted delivery of hydrophilic drugs is an important field within drug
delivery, presenting unique challenges when compared to that of hydrophobic drugs. Yet …
delivery, presenting unique challenges when compared to that of hydrophobic drugs. Yet …
Academia Europaea position paper on translational medicine: the cycle model for translating scientific results into community benefits
Introduction: Translational science has gained prominence in medicine, but there is still
much work to be done before scientific results are used optimally and incorporated into …
much work to be done before scientific results are used optimally and incorporated into …
The evolution of current concept of the reconstructive ladder in plastic surgery: the emerging role of translational medicine
Plastic surgeons have used the reconstructive ladder for many decades as a standard
directory for complex trauma reconstruction with the goal of repairing body structures and …
directory for complex trauma reconstruction with the goal of repairing body structures and …
Filling the gap: neural stem cells as a promising therapy for spinal cord injury
Spinal cord injury (SCI) can lead to severe motor, sensory and social impairments having a
huge impact on patients' lives. The complex and time-dependent SCI pathophysiology has …
huge impact on patients' lives. The complex and time-dependent SCI pathophysiology has …
Drugs for preventing lung cancer in healthy people
M Cortés‐Jofré, JR Rueda… - Cochrane Database …, 2020 - cochranelibrary.com
Background This is the second update of this Cochrane Review. Some studies have
suggested a protective effect of antioxidant nutrients and higher dietary levels of fruits and …
suggested a protective effect of antioxidant nutrients and higher dietary levels of fruits and …