Sigma-1 receptor (S1R) is a multi-functional, ligand-operated protein situated in
endoplasmic reticulum (ER) membranes and changes in its function and/or expression have …

Inter-organelle signaling plays important roles in many physiological functions. Endoplasmic
reticulum (ER)–mitochondrion signaling affects intramitochondrial calcium (Ca 2+) …

The sigma-1 receptor is widely distributed in the central nervous system and periphery.
Originally mischaracterized as an opioid receptor, the sigma-1 receptor binds a vast number …

Sigma () receptors, initially described as a subtype of opioid receptors, are now considered
unique receptors. Pharmacological studies have distinguished two types of receptors …

Background: Widespread protein aggregation occurs in the living system under stress or
during aging, owing to disturbance of endoplasmic reticulum (ER) proteostasis. Many …

Depression and cognitive disorders are diseases with complex and not-fully understood
etiology. Unfortunately, the COVID-19 pandemic dramatically increased the prevalence of …

Since their discovery as distinct receptor proteins, the specific physiopathological role of
sigma receptors (σRs) has been deeply investigated. It has been reported that these …

Sigma 1 receptor (S1R) is a 223-amino-acid-long transmembrane endoplasmic reticulum
(ER) protein. S1R modulates activity of multiple effector proteins and is a well-established …

The sigma-1 receptor (S1R) is a 223-amino-acid membrane protein that resides in the
endoplasmic reticulum and the plasma membrane of some mammalian cells. The S1R is …

The remodeling of calcium homeostasis contributes to the cancer hallmarks and the
molecular mechanisms involved in calcium channel regulation in tumors remain to be …