Interpretation of the effect of CYP2C9, VKORC1 and CYP4F2 variants on warfarin dosing adjustment in Turkey

A Kocael, AP Eronat, MB Tüzüner, A Ekmekçi… - Molecular biology …, 2019 - Springer
It was aimed to underline the importance and explain the meaning of genetic testing in
warfarin dosing and investigate and evaluate the contributions of the CYP2C9, VKORC1 …

Determining the adjusted initial treatment dose of warfarin anticoagulant medicine using kernel-based support vector regression

R Maghsoudi, M Mirzarezaee, M Sadeghi… - Computer methods and …, 2022 - Elsevier
Background and objective A novel research field in bioinformatics is pharmacogenomics
and the corresponding applications of artificial intelligence tools. Pharmacogenomics is the …

Pharmacogenomics of anticoagulation therapy: the last 10 years

G Ragia, VG Manolopoulos - Pharmacogenomics, 2019 - Taylor & Francis
Since 2009, six main developments have occurred in this field: several RCTs aiming to
assess the safety and clinical utility of newly developed pharmacogenomic-guided dosing …

Evaluation of a warfarin dosing algorithm including CYP2C9, VKORC1, and CYP4F2 polymorphisms and non-genetic determinants for the Iranian population

M Farajzadeh-Dehkordi, F Samiee-Rad… - Pharmacological …, 2023 - Springer
Background The response to warfarin, as an oral anticoagulant agent, varies widely among
patients from different ethnic groups. In this study, we tried to ascertain and determine the …

Pharmacogenomics-based practice in North Cyprus: its adoption by pharmacists and their attitudes and knowledge

L Alsaloumi, A Abdi, Ö Tosun, B Başgut - International journal of clinical …, 2019 - Springer
Background Pharmacogenomics is a branch of biotechnological science integrating
medicine, pharmacology, and genomics techniques. Moreover, it focuses on creating drug …

Warfarin pharmacogenomics in African populations: the importance of ethnicity-based algorithms

M Jallul, I Alhudiri, L Al-Eitan, A Elzagheid - Pharmacogenomics, 2022 - Taylor & Francis
Full article: Warfarin Pharmacogenomics in African Populations: The Importance of Ethnicity-Based
Algorithms Skip to Main Content Taylor and Francis Online homepage Taylor and Francis …

A novel acenocoumarol pharmacogenomic dosing algorithm for the Greek population of EU-PACT trial

G Ragia, V Kolovou, G Kolovou… - …, 2017 - Taylor & Francis
Aim: To generate and validate a pharmacogenomic-guided (PG) dosing algorithm for
acenocoumarol in the Greek population. To compare its performance with other PG …

Allergy-specific phenome-wide association study for immunogenes in Turkish children

S Karaca, E Civelek, M Karaca, UM Sahiner… - Scientific reports, 2016 - nature.com
To dissect the role of immunogenetics in allergy and asthma, we performed a phenome-
wide association study in 974 Turkish children selected from a cross-sectional study …

Nutritional habits, lifestyle, and genetic predisposition in cardiovascular and metabolic traits in Turkish population

S Karaca, S Erge, T Cesuroglu, R Polimanti - Nutrition, 2016 - Elsevier
Objectives Cardiovascular and metabolic traits (CMT) are influenced by complex interactive
processes including diet, lifestyle, and genetic predisposition. The present study …

Haplotype analysis of non-HLA immunogenetic loci in Turkish and worldwide populations

S Karaca, M Karaca, E Civelek, RK Ozgul, BE Sekerel… - Gene, 2016 - Elsevier
Immunogenes (ie, genes related to the immune system and its functions) are involved in the
predisposition to numerous traits and their variation contributes to the phenotypic variability …