Cytosolic Ca2+ signals are organized in complex spatial and temporal patterns that underlie
their unique ability to regulate multiple cellular functions. Changes in intracellular Ca2+ …

All animal cells control their volume through a complex set of mechanisms, both to
counteract osmotic perturbations of the environment and to enable numerous vital biological …

The microgeometry of the cellular microenvironment profoundly impacts cellular behaviors,
yet the link between it and the ubiquitously expressed mechanosensitive ion channel …

Blood flow–induced hemodynamic changes result in mechanical stress on blood cells and
vessel walls. Increased shear stress can activate platelets and other circulating cells …

Mechanosensitive ion channels sense mechanical stimuli applied directly to the cellular
membranes or indirectly through their tethered components, provoking cellular …

Aqueous humor drainage from the anterior eye determines intraocular pressure (IOP) under
homeostatic and pathological conditions. Swelling of the trabecular meshwork (TM) alters its …

Mammalian expression systems, particularly the human embryonic kidney (HEK-293) cells,
combined with electrophysiological studies, have greatly benefited our understanding of the …

The solute carrier family 12 (SLC12) of cation-chloride cotransporters (CCCs) comprises
potassium chloride cotransporters (KCCs, eg KCC1, KCC2, KCC3, and KCC4)-mediated …

Glioblastoma (GBM), the most lethal form of brain tumors, bases its malignancy on the strong
ability of its cells to migrate and invade the narrow spaces of healthy brain parenchyma. Cell …

The malignancy of glioblastoma (GBM), the most aggressive type of human brain tumor,
strongly correlates with the presence of hypoxic areas within the tumor mass. Oxygen levels …