The oligonucleotide therapeutics field has seen remarkable progress over the last few years
with the approval of the first antisense drug and with promising developments in late stage …

Functional nucleic acid (NA)-based drugs have a broad range of applications since they
allow the alteration and control of gene/protein expression patterns in cells. In principle …

Aptamers are a class of small nucleic acid ligands that are composed of RNA or single-
stranded DNA oligonucleotides and have high specificity and affinity for their targets. Similar …

Aptamers are single-stranded nucleic acid sequences that can bind to target molecules with
high selectivity and affinity. Most aptamers are screened in vitro by a combinatorial biology …

One hundred years ago, Dr. Paul Ehrlich popularized the" magic bullet" concept for cancer
therapy in which an ideal therapeutic agent would only kill the specific tumor cells it targeted …

Nucleic acid aptamers are single-stranded oligonucleotides that interact with target
molecules with high affinity and specificity in unique three-dimensional structures. Aptamers …

The advent of the technology of using B lymphocyte hybridomas to produce monoclonal
antibodies (mAbs) in the 1970s gave the medical world a ray of hope to conquer cancers …

Aptamers are RNA/DNA oligonucleotide molecules that specifically bind to a targeted
complementary molecule. As potential recognition elements with promising diagnostic and …

The selective delivery of drugs in a cell-or tissue-specific manner represents the main
challenge for medical research; in order to reduce the occurrence of unwanted off-target …

Small interfering RNA (siRNA) has gained attention as a potential therapeutic reagent due to
its ability to inhibit specific genes in many genetic diseases. For many years, studies of …