Mesenchymal stem/stromal cells as a valuable source for the treatment of immune-mediated disorders

A Markov, L Thangavelu, S Aravindhan… - Stem cell research & …, 2021 - Springer
Over recent years, mesenchymal stem/stromal cells (MSCs) and their potential biomedical
applications have received much attention from the global scientific community in an …

Exosome engineering in cell therapy and drug delivery

S Sadeghi, FR Tehrani, S Tahmasebi, A Shafiee… - …, 2023 - Springer
Cell-derived exosomes have opened new horizons in modern therapy for advanced drug
delivery and therapeutic applications, due to their key features such as low immunogenicity …

Role of inflammatory cytokines in COVID-19 patients: A review on molecular mechanisms, immune functions, immunopathology and immunomodulatory drugs to …

AA Rabaan, SH Al-Ahmed, J Muhammad, A Khan… - Vaccines, 2021 - mdpi.com
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), is a severe pandemic of the current century. The vicious …

Mesenchymal stem cells in fibrotic diseases—the two sides of the same coin

L Qin, N Liu, C Bao, D Yang, G Ma, W Yi… - Acta Pharmacologica …, 2023 - nature.com
Fibrosis is caused by extensive deposition of extracellular matrix (ECM) components, which
play a crucial role in injury repair. Fibrosis attributes to~ 45% of all deaths worldwide. The …

Diverse immunological factors influencing pathogenesis in patients with COVID-19: a review on viral dissemination, immunotherapeutic options to counter cytokine …

AA Rabaan, SH Al-Ahmed, MA Garout, AM Al-Qaaneh… - Pathogens, 2021 - mdpi.com
The pathogenesis of coronavirus disease 2019 (COVID-19), caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), is still not fully unraveled. Though …

Mesenchymal stem cell-based treatments for COVID-19: status and future perspectives for clinical applications

L Chen, J Qu, FS Kalyani, Q Zhang, L Fan… - Cellular and Molecular …, 2022 - Springer
As a result of cross-species transmission in December 2019, the coronavirus disease 2019
(COVID-19) became a serious endangerment to human health and the causal agent of a …

Human placenta-derived mesenchymal stem cells transplantation in patients with acute respiratory distress syndrome (ARDS) caused by COVID-19 (phase I clinical …

HR Aghayan, F Salimian, A Abedini… - Stem cell research & …, 2022 - Springer
Background High morbidity and mortality rates of the COVID-19 pandemic have made it a
global health priority. Acute respiratory distress syndrome (ARDS) is one of the most …

Safety of DW-MSC infusion in patients with low clinical risk COVID-19 infection: a randomized, double-blind, placebo-controlled trial

M Karyana, I Djaharuddin, L Rif'ati, M Arif… - Stem cell research & …, 2022 - Springer
Background Due to their immunomodulatory properties, mesenchymal stem cells (MSCs)
have been proposed to have therapeutic potential to improve clinical outcomes in COVID …

Mesenchymal stromal/stem cells and their extracellular vesicles application in acute and chronic inflammatory liver diseases: emphasizing on the anti-fibrotic and …

A Hazrati, K Malekpour, S Soudi… - Frontiers in …, 2022 - frontiersin.org
Various factors, including viral and bacterial infections, autoimmune responses, diabetes,
drugs, alcohol abuse, and fat deposition, can damage liver tissue and impair its function …

Mesenchymal stem/stromal cells and their paracrine activity—immunomodulation mechanisms and how to influence the therapeutic potential

R Alvites, M Branquinho, AC Sousa, B Lopes, P Sousa… - Pharmaceutics, 2022 - mdpi.com
With high clinical interest to be applied in regenerative medicine, Mesenchymal
Stem/Stromal Cells have been widely studied due to their multipotency, wide distribution …