Cell–cell communication: new insights and clinical implications
J Su, Y Song, Z Zhu, X Huang, J Fan, J Qiao… - Signal Transduction and …, 2024 - nature.com
Multicellular organisms are composed of diverse cell types that must coordinate their
behaviors through communication. Cell–cell communication (CCC) is essential for growth …
behaviors through communication. Cell–cell communication (CCC) is essential for growth …
Perspective on the current state of the LRRK2 field
Almost 2 decades after linking LRRK2 to Parkinson's disease, a vibrant research field has
developed around the study of this gene and its protein product. Recent studies have begun …
developed around the study of this gene and its protein product. Recent studies have begun …
Preclinical and clinical evaluation of the LRRK2 inhibitor DNL201 for Parkinson's disease
Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common genetic risk factors
for Parkinson's disease (PD). Increased LRRK2 kinase activity is thought to impair lysosomal …
for Parkinson's disease (PD). Increased LRRK2 kinase activity is thought to impair lysosomal …
Role of exosomal proteins in cancer diagnosis
W Li, C Li, T Zhou, X Liu, X Liu, X Li, D Chen - Molecular cancer, 2017 - Springer
Exosomes are emerging as a new type of cancer biomarkers. Exosome is a bilayered nano-
sized vesicle secreted by various living cells in all body fluids. Based on the expanding …
sized vesicle secreted by various living cells in all body fluids. Based on the expanding …
LRRK2 phosphorylates membrane-bound Rabs and is activated by GTP-bound Rab7L1 to promote recruitment to the trans-Golgi network
Human genetic studies implicate LRRK2 and RAB7L1 in susceptibility to Parkinson disease
(PD). These two genes function in the same pathway, as knockout of Rab7L1 results in …
(PD). These two genes function in the same pathway, as knockout of Rab7L1 results in …
The potential use of mesenchymal stem cells and their exosomes in Parkinson's disease treatment
Parkinson's disease (PD) is the second most predominant neurodegenerative disease
worldwide. It is recognized clinically by severe complications in motor function caused by …
worldwide. It is recognized clinically by severe complications in motor function caused by …
Exosomes in Parkinson disease
JR Pinnell, M Cui, K Tieu - Journal of neurochemistry, 2021 - Wiley Online Library
Parkinson disease (PD) is a prevalent neurodegenerative disease, in which the formation of
misfolded and aggregated α‐synuclein is a key neuropathological hallmark. Recent studies …
misfolded and aggregated α‐synuclein is a key neuropathological hallmark. Recent studies …
LRRK2 antisense oligonucleotides ameliorate α-synuclein inclusion formation in a Parkinson's disease mouse model
HT Zhao, N John, V Delic, K Ikeda-Lee, A Kim… - … Therapy-Nucleic Acids, 2017 - cell.com
No treatments exist to slow or halt Parkinson's disease (PD) progression; however, inhibition
of leucine-rich repeat kinase 2 (LRRK2) activity represents one of the most promising …
of leucine-rich repeat kinase 2 (LRRK2) activity represents one of the most promising …
[HTML][HTML] Achieving neuroprotection with LRRK2 kinase inhibitors in Parkinson disease
AB West - Experimental neurology, 2017 - Elsevier
In the translation of discoveries from the laboratory to the clinic, the track record in
develo** disease-modifying therapies in neurodegenerative disease is poor. A carefully …
develo** disease-modifying therapies in neurodegenerative disease is poor. A carefully …
Proteomic analysis of urinary extracellular vesicles reveal biomarkers for neurologic disease
Abstract Background Extracellular vesicles (EVs) harbor thousands of proteins that hold
promise for biomarker development. Usually difficult to purify, EVs in urine are relatively …
promise for biomarker development. Usually difficult to purify, EVs in urine are relatively …