The interplay of metabolic and epigenetic players in disease development

P Chakraborty, C Mukherjee - Biochemical and Biophysical Research …, 2024 - Elsevier
Epigenetic modifications and their alterations can cause variation in gene expression
patterns which can ultimately affect a healthy individual. Until a few years ago, it was thought …

Cyproheptadine inhibits in vitro and in vivo lung metastasis and drives metabolic rewiring

A Shannar, MS Sarwar, PD Dave, PCJ Chou… - Molecular Biology …, 2024 - Springer
Background Non-small cell lung cancer (NSCLC) accounts for 81% of lung cancer cases,
among which over 47% presented with distant metastasis at the time of diagnosis. Despite …

Hederagenin attenuates renal senescence in diabetic kidney disease by inhibiting DNMT1-mediated Klotho DNA methylation

G Luo, M Liu, W Yu, H Liu, J Zhou, D Li, F Chen… - 2024 - researchsquare.com
Renal senescence plays a crucial role in the development of diabetic kidney disease (DKD).
The progression of DKD can accelerate the senescence process of the kidney, making it …

[CITATION][C] Causal Association Between Adipokines And Lung Cancers: A Two-Sample Mendelian Randomization Study

YC Lin, Z Cheng, J Zeng, Y Wang