Metastases represent the end products of a multistep cell-biological process termed the
invasion-metastasis cascade, which involves dissemination of cancer cells to anatomically …

Since its discovery, the STAT3 transcription factor has been extensively studied for its
function as a transcriptional regulator and its role as a mediator of development, normal …

Covering 2000 to June 2015 This review discusses the biosynthesis of natural products that
are generated by trans-AT polyketide synthases, a family of catalytically versatile enzymes …

Natural products (NPs) are important sources of clinical drugs due to their structural diversity
and biological prevalidation. However, the structural complexity of NPs leads to synthetic …

Tunneling nanotubes are long, non-adherent F-actin-based cytoplasmic extensions which
connect proximal or distant cells and facilitate intercellular transfer. The identification of …

Metastasis is the leading cause of breast cancer-associated deaths. Despite the significant
improvement in current therapies in extending patient life, 30–40% of patients may …

Ras-associated protein-1 (Rap1), a small GTPase in the Ras-related protein family, is an
important regulator of basic cellular functions (eg, formation and control of cell adhesions …

Chemo-immunotherapy holds the advantage of specific antitumor effects by activating T cell
immune response. However, the efficiency of chemo-immunotherapy is restricted to the …

Breast cancer represents a highly heterogeneous disease comprised by several subtypes
with distinct histological features, underlying molecular etiology and clinical behaviors. It is …

F-actin (filamentous actin) has been shown to be sensitive to mechanical stimuli and play
critical roles in cell attachment, migration, and cancer metastasis, but there are very limited …