Calpains are a family of Ca 2+‑dependent cysteine proteases that participate in various
cellular processes. Calpain 3 (CAPN3) is a classical calpain with unique N‑terminus and …

Limb-girdle muscular dystrophy recessive 1 (LGMDR1), previously known as LGMD2A, is a
rare disease caused by mutations in the CAPN3 gene. It is characterized by progressive …

Abstract Excessive calcium (Ca 2+) release from the endoplasmic reticulum (ER) represents
an important hallmark of several neurodegenerative diseases. ER is recharged from Ca 2+ …

The remodelling of neuronal ionic homeostasis by altered channels and transporters is a
critical feature of the Alzheimer's disease (AD) pathogenesis. Different reports converge on …

Eccentric exercise training is effective for increasing muscle mass and strength, and
improving insulin sensitivity and blood lipid profiles. However, potential muscle damage …

A new coumarin-based fluorescent probe, containing an allylic esters group, has been
designed and synthesized for sensing cysteine in physiological pH. In this fluorescent probe …

Febrile seizure (FS) counts as the most common seizures symptom in children undergoing
recurrent seizures, posing a high risk to develo** subsequent temporal lobe epilepsy …

Although the increased understanding of nuclear envelope functions has made it harder to
distinguish specific causes of nuclear envelope disorders, this is because it has greatly …

Limb girdle muscular dystrophy type R1 disease is a progressive disease that is caused by
mutations in the CAPN3 gene and involves the extremity muscles of the hip and shoulder …

Limb girdle muscular dystrophy type 2A (LGMD2A) is an autosomal recessive disorder
characterized by progressive muscle weakness and wasting. LGMD2A is caused by …