BAG3: nature's quintessential multi-functional protein functions as a ubiquitous intra-cellular glue
CM Brenner, M Choudhary, MG McCormick, D Cheung… - Cells, 2023 - mdpi.com
BAG3 is a 575 amino acid protein that is found throughout the animal kingdom and
homologs have been identified in plants. The protein is expressed ubiquitously but is most …
homologs have been identified in plants. The protein is expressed ubiquitously but is most …
Targeting calpain-2-mediated junctophilin-2 cleavage delays heart failure progression following myocardial infarction
Coronary heart disease (CHD) is a prevalent cardiac disease that causes over 370,000
deaths annually in the USA. In CHD, occlusion of a coronary artery causes ischemia of the …
deaths annually in the USA. In CHD, occlusion of a coronary artery causes ischemia of the …
The cytoplasmic sensor, the AIM2 inflammasome: A precise therapeutic target in vascular and metabolic diseases
J Lin, J Wang, J Fang, M Li, S Xu… - British Journal of …, 2024 - Wiley Online Library
Cardio‐cerebrovascular diseases encompass pathological changes in the heart, brain and
vascular system, which pose a great threat to health and well‐being worldwide. Moreover …
vascular system, which pose a great threat to health and well‐being worldwide. Moreover …
[HTML][HTML] Force-induced dephosphorylation activates the cochaperone BAG3 to coordinate protein homeostasis and membrane traffic
J Ottensmeyer, A Esch, H Baeta, S Sieger, Y Gupta… - Current Biology, 2024 - cell.com
Proteome maintenance in contracting skeletal and cardiac muscles depends on the
chaperone-regulating protein BAG3. Reduced BAG3 activity leads to muscle weakness and …
chaperone-regulating protein BAG3. Reduced BAG3 activity leads to muscle weakness and …
[HTML][HTML] Dilated cardiomyopathy due to a novel combination of TTN and BAG3 genetic variants: From acute heart failure to subclinical phenotypes
Dilated cardiomyopathy (DCM) is defined as left ventricular enlargement accompanied by
systolic dysfunction not explained by abnormal loading conditions or coronary heart …
systolic dysfunction not explained by abnormal loading conditions or coronary heart …
BAG3 localizes to mitochondria in cardiac fibroblasts and regulates mitophagy
The co-chaperone Bcl2-associated athanogene 3 (BAG3) is a central node in protein quality
control in the heart. In humans and animal models, decreased BAG3 expression is …
control in the heart. In humans and animal models, decreased BAG3 expression is …
Corelating the molecular structure of BAG3 to its oncogenic role
TS Pattoo, FA Khanday - Cell Biology International, 2024 - Wiley Online Library
BAG3 is a multifaceted protein characterised by having WW domain, PXXP motif and BAG
domain. This protein gets upregulated during malignant transformation of cells and has …
domain. This protein gets upregulated during malignant transformation of cells and has …
[HTML][HTML] BAG3 in the Heart
MC Turco - Basic to Translational Science, 2023 - jacc.org
JACC: Basic to Translational Science belongs to the line of studies investigating the
activities of BAG3 protein in cardiomyocytes and constitutes a significant step forward in …
activities of BAG3 protein in cardiomyocytes and constitutes a significant step forward in …
Uncovering the Dual Role of Mitochondrial and Nuclear DNA Variants in Pediatric Cardiomyopathies
The diagnosis, categorization, and management of isolated non-syndromic pediatric
cardiomyopathies now heavily depend on genetic research. Defects in the myocardium may …
cardiomyopathies now heavily depend on genetic research. Defects in the myocardium may …
[CITATION][C] BAG3 in cardiovascular diseases
N De Maio, M De Marco - Cardiovascular Pathology, 2024 - iris.unisa.it
BAG3 in cardiovascular diseases IRIS IRIS Home Sfoglia Macrotipologie & tipologie Autore
Titolo Riviste Serie IT Italiano Italiano English English LOGIN 1.IRIS 2.Catalogo Prodotti Ricerca …
Titolo Riviste Serie IT Italiano Italiano English English LOGIN 1.IRIS 2.Catalogo Prodotti Ricerca …