Implant dentistry has evolved to the point that standard implant osseointegration is
predictable. This is attributed in part to the advancements in material sciences that have led …

Metal implants are essential therapeutic tools for the treatment of bone fractures and joint
replacements. The metals and metal alloys used in contemporary orthopedic and trauma …

Caspase-3 is a critical enzyme for apoptosis and cell survival. Here we report delayed
ossification and decreased bone mineral density in caspase-3–deficient (Casp3–/–and …

Aseptic loosening of orthopedic implants is thought to be caused primarily by osteoclast
differentiation induced by bone resorptive cytokines produced in response to phagocytosis …

Study Design. Generally, implant-induced osteolysis is a manifestation of an adverse
cellular response to phagocytosable particulate wear and corrosion debris. Initially termed …

Aseptic loosening of orthopedic implants caused by wear particles is a major clinical
problem. This review examines the hypothesis that bacterial endotoxin contributes to aseptic …

Dentistry and orthopedics are undergoing a revolution in order to provide more reliable,
comfortable and long-lasting implants to patients. Titanium (Ti) and titanium alloys have …

Prosthesis failure due to wear debris‐induced osteolysis remains a major clinical problem
and the greatest limitation for total joint arthroplasty. Based on our knowledge of osteoclast …

Objectives Metallic element release during implant placement can lead to mucositis and peri-
implantitis. Here, using ex vivo porcine mandibles, the release of metallic elements into the …

Background: Loosening of orthopaedic implants is mediated by cytokines that elicit bone
resorption and are produced in response to phagocytosis of implant-derived wear particles …