Structural biologists have traditionally approached cellular complexity in a reductionist
manner in which the cellular molecular components are fractionated and purified before …

Filopodia are thin, actin-rich plasma-membrane protrusions that function as antennae for
cells to probe their environment. Consequently, filopodia have an important role in cell …

Actin filaments are major components of at least 15 distinct structures in metazoan cells.
These filaments assemble from a common pool of actin monomers, but do so at different …

The growth and migration of neurons require continuous remodelling of the neuronal
cytoskeleton, providing a versatile cellular framework for force generation and guided …

The orchestration of intercellular communication is essential for multicellular organisms. One
mechanism by which cells communicate is through long, actin-rich membranous protrusions …

Cryo-electron tomography is a powerful technique that can faithfully image the native
cellular environment at nanometer resolution. Unlike many other imaging approaches, cryo …

Filopodia are actin-based structures composed of parallel bundles of actin filaments and
various actin-associated proteins, and they play important roles in cell-cell signaling …

The hemoglobins S and C protect carriers from severe Plasmodium falciparum malaria.
Here, we found that these hemoglobinopathies affected the trafficking system that directs …

A cell constantly adapts to its environment. Cell decisions to survive, to proliferate or to
migrate are dictated not only by soluble growth factors, but also through the direct interaction …

Fluorescence polarization microscopy images both the intensity and orientation of
fluorescent dipoles and plays a vital role in studying molecular structures and dynamics of …