Mammalian skeletal muscle comprises different fiber types, whose identity is first established
during embryonic development by intrinsic myogenic control mechanisms and is later …

There is a pandemic of physical inactivity that appears to parallel the widespread
prevalence of cardiovascular disease (CVD). Yet, regular physical activity (PA) and exercise …

Physical exercise represents a major challenge to whole-body homeostasis, provoking
acute and adaptative responses at the cellular and systemic levels. Different sources of …

Skeletal muscle fitness and plasticity is an important determinant of human health and
disease. Mitochondria are essential for maintaining skeletal muscle energy homeostasis by …

Mitochondria play central roles in energy homeostasis, metabolism, signaling, and
apoptosis. Accordingly, the abundance, morphology, and functional properties of …

Skeletal muscle plays an important role in regulating whole-body energy expenditure given
it is a major site for glucose and lipid oxidation. Obesity and type 2 diabetes are causally …

To maintain and restore skeletal muscle mass and function is essential for healthy aging. We
have found that myonectin acts as a cardioprotective myokine. Here, we investigate the …

Impaired mitochondrial function often results in excessive production of reactive oxygen
species (ROS) and is involved in the etiology of many chronic diseases, including …

Peripheral arterial disease (PAD) affects 5 million people in the US and is the primary cause
of limb amputations. Exercise remains the single best intervention for PAD, in part thought to …

The purpose of this study was to investigate the effects of high-intensity interval training
(HIIT) and moderate-intensity continuous training (MICT) on the skeletal muscle in …