Ovarian cancer is one of the leading causes of death in patients with gynecological
malignancy. Despite optimal cytoreductive surgery and platinum-based chemotherapy …

Fibroblasts have exceptional phenotypic plasticity and capability to secrete vast amount of
soluble factors, extracellular matrix components and extracellular vesicles. While in …

Elevated production of collagen-rich extracellular matrix is a hallmark of cancer-associated
fibroblasts (CAFs) and a central driver of cancer aggressiveness. Here we find that proline, a …

Background Kaempferol, a natural flavonoid, exhibits anticancer properties by scavenging
reactive oxygen species (ROS). However, increasing evidence has demonstrated that …

Extracellular vesicles (EVs), as natural carriers of bioactive cargo, have a unique
micro/nanostructure, bioactive composition, and characteristic morphology, as well as …

Ovarian cancer is the leading cause of gynecological cancer-related mortality globally. The
majority of ovarian cancer patients suffer from relapse after standard of care therapies and …

Tumor progression alters the composition and physical properties of the extracellular matrix.
Particularly, increased matrix stiffness has profound effects on tumor growth and metastasis …

Adequate blood supply is essential for tumor survival, growth and metastasis. The tumor
microenvironment (TME) is dynamic and complex, comprising cancer cells, cancer …

Ion channels are integral membrane proteins present on the plasma membrane as well as
intracellular membranes. In the human genome, there are more than 400 known genes …

Intratumoral hypoxia causes the formation of dysfunctional blood vessels, which contribute
to tumor metastasis and reduce the efficacy of therapeutic treatments. Blood vessels are …