Targeting fibrosis: Mechanisms and clinical trials
M Zhao, L Wang, M Wang, S Zhou, Y Lu… - Signal transduction and …, 2022 - nature.com
Fibrosis is characterized by the excessive extracellular matrix deposition due to
dysregulated wound and connective tissue repair response. Multiple organs can develop …
dysregulated wound and connective tissue repair response. Multiple organs can develop …
Hepatic fibrosis 2022: Unmet needs and a blueprint for the future
Steady progress over four decades toward understanding the pathogenesis and clinical
consequences of hepatic fibrosis has led to the expectation of effective antifibrotic drugs, yet …
consequences of hepatic fibrosis has led to the expectation of effective antifibrotic drugs, yet …
Liver fibrosis: Pathophysiology, pathogenetic targets and clinical issues
The progression of chronic liver diseases (CLD), irrespective of etiology, involves chronic
parenchymal injury, persistent activation of inflammatory response as well as sustained …
parenchymal injury, persistent activation of inflammatory response as well as sustained …
Mechanisms of fibrosis development in nonalcoholic steatohepatitis
Nonalcoholic fatty liver disease is the most prevalent liver disease worldwide, affecting 20%–
25% of the adult population. In 25% of patients, nonalcoholic fatty liver disease progresses …
25% of the adult population. In 25% of patients, nonalcoholic fatty liver disease progresses …
Apoptosis and necroptosis in the liver: a matter of life and death
Cell death represents a basic biological paradigm that governs outcomes and long-term
sequelae in almost every hepatic disease condition. Acute liver failure is characterized by …
sequelae in almost every hepatic disease condition. Acute liver failure is characterized by …
Milk thistle (Silybum marianum): A concise overview on its chemistry, pharmacological, and nutraceutical uses in liver diseases
Milk thistle (MT; Silybum marianum), a member of the Asteraceae family, is a therapeutic
herb with a 2,000‐year history of use. MT fruits contain a mixture of flavonolignans …
herb with a 2,000‐year history of use. MT fruits contain a mixture of flavonolignans …
Liver immunology and its role in inflammation and homeostasis
The human liver is usually perceived as a non-immunological organ engaged primarily in
metabolic, nutrient storage and detoxification activities. However, we now know that the …
metabolic, nutrient storage and detoxification activities. However, we now know that the …
[HTML][HTML] Tetramethylpyrazine: A review on its mechanisms and functions
J Lin, Q Wang, S Zhou, S Xu, K Yao - Biomedicine & Pharmacotherapy, 2022 - Elsevier
Ligusticum chuanxiong Hort (known as Chuanxiong in China, CX) is one of the most widely
used and long-standing medicinal herbs in China. Tetramethylpyrazine (TMP) is an alkaloid …
used and long-standing medicinal herbs in China. Tetramethylpyrazine (TMP) is an alkaloid …
NF-κB restricts inflammasome activation via elimination of damaged mitochondria
Nuclear factor κB (NF-κB), a key activator of inflammation, primes the NLRP3-inflammasome
for activation by inducing pro-IL-1β and NLRP3 expression. NF-κB, however, also prevents …
for activation by inducing pro-IL-1β and NLRP3 expression. NF-κB, however, also prevents …
HK1 from hepatic stellate cell–derived extracellular vesicles promotes progression of hepatocellular carcinoma
Q Chen, Z Zhang, Q Huang, H Chen, W Hong, T Lin… - Nature …, 2022 - nature.com
Extracellular vesicles play crucial roles in intercellular communication in the tumor
microenvironment. Here we demonstrate that in hepatic fibrosis, TGF-β stimulates the …
microenvironment. Here we demonstrate that in hepatic fibrosis, TGF-β stimulates the …