Regulation of the immune response by the aryl hydrocarbon receptor
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that is
activated by small molecules provided by the diet, microorganisms, metabolism, and …
activated by small molecules provided by the diet, microorganisms, metabolism, and …
The role of the aryl hydrocarbon receptor (AHR) in immune and inflammatory diseases
The aryl hydrocarbon receptor (AHR) is a nuclear receptor that modulates the response to
environmental stimuli. It was recognized historically for its role in toxicology but, in recent …
environmental stimuli. It was recognized historically for its role in toxicology but, in recent …
Aryl hydrocarbon receptor (AHR):“pioneer member” of the basic-helix/loop/helix per-Arnt-sim (bHLH/PAS) family of “sensors” of foreign and endogenous signals
DW Nebert - Progress in lipid research, 2017 - Elsevier
The basic-helix/loop/helix per-Arnt-sim (bHLH/PAS) family comprises many transcription
factors, found throughout all three kingdoms of life; bHLH/PAS members “sense” …
factors, found throughout all three kingdoms of life; bHLH/PAS members “sense” …
The aryl hydrocarbon receptor and the gut–brain axis
The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor initially
identified as the receptor for dioxin. Almost half a century after its discovery, AHR is now …
identified as the receptor for dioxin. Almost half a century after its discovery, AHR is now …
ROS and Trypanosoma cruzi: Fuel to infection, poison to the heart
The activation of macrophage respiratory burst in response to infection with Trypanosoma
cruzi inflicts oxidative damage to the host's tissues. For decades, the role of reactive oxygen …
cruzi inflicts oxidative damage to the host's tissues. For decades, the role of reactive oxygen …
The role of the AHR in host–pathogen interactions
Host–microorganism encounters take place in many different ways and with different types
of outcomes. Three major types of microorganisms need to be distinguished:(1) pathogens …
of outcomes. Three major types of microorganisms need to be distinguished:(1) pathogens …
[HTML][HTML] Immunity and vaccine development efforts against Trypanosoma cruzi
Trypanosoma cruzi (T. cruzi) is the causative agent for Chagas disease (CD). There is a
critical lack of methods for prevention of infection or treatment of acute infection and chronic …
critical lack of methods for prevention of infection or treatment of acute infection and chronic …
Indoxyl sulfate activates NLRP3 inflammasome to induce cardiac contractile dysfunction accompanied by myocardial fibrosis and hypertrophy
K Yamaguchi, M Yisireyili, S Goto, XW Cheng… - Cardiovascular …, 2022 - Springer
In patients with chronic kidney diseases (CKD), high serum indoxyl sulfate (IS) levels
correlate with cardiac fibrosis and hypertrophy and thus a critical risk factor for heart failure …
correlate with cardiac fibrosis and hypertrophy and thus a critical risk factor for heart failure …
Benzo (a) pyrene facilitates dermatophagoides group 1 (Der f 1)‐induced epithelial cytokine release through aryl hydrocarbon receptor in asthma
E Wang, X Liu, W Tu, DC Do, H Yu, L Yang, Y Zhou… - Allergy, 2019 - Wiley Online Library
Background Environmental pollutants, which coexist with allergens, have been associated
with the exacerbation of asthma. However, the underlying molecular mechanisms remain …
with the exacerbation of asthma. However, the underlying molecular mechanisms remain …
Aryl hydrocarbon receptor: a new player of pathogenesis and therapy in cardiovascular diseases
T Yi, J Wang, K Zhu, Y Tang, S Huang… - BioMed research …, 2018 - Wiley Online Library
The aryl hydrocarbon receptor (AhR) is a DNA binding protein that acts as a nuclear
receptor mediating xenobiotic metabolism and environmental responses. Owing to the …
receptor mediating xenobiotic metabolism and environmental responses. Owing to the …