Despite advances in molecular biology, genetics, computation, and medicinal chemistry,
infectious disease remains an ominous threat to public health. Addressing the challenges …

Recent pandemics, including the COVID-19 outbreak, have brought up growing concerns
about transmission of zoonotic diseases from animals to humans. This highlights the …

Sequence-based analysis and prediction are fundamental bioinformatic tasks that facilitate
understanding of the sequence (-structure)-function paradigm for DNAs, RNAs and proteins …

Spatial structures of proteins are closely related to protein functions. Integrating protein
structures improves the performance of protein–protein interaction (PPI) prediction …

Protein–protein interactions (PPIs) carry out the cellular processes of all living organisms.
Experimental methods for PPI detection suffer from high cost and false-positive rate, hence …

To adequately prepare for potential hazards caused by emerging and reemerging infectious
diseases, the WHO has issued a list of high-priority pathogens that are likely to cause future …

Conventional supervised binary classification algorithms have been widely applied to
address significant research questions using biological and biomedical data. This …

Proteins are the fundamental biological macromolecules which underline practically all
biological activities. Protein–protein interactions (PPIs), as they are known, are how proteins …

Host-microbiome interactions play significant roles in human health and disease. Artificial
intelligence approaches have been developed to better understand and predict the …

Parasitic fungi produce proteins that modulate virulence, alter host physiology, and trigger
host responses. These proteins, classified as a type of “effector,” often act via protein–protein …