Mass spectrometry using electrospray ionization

GRD Prabhu, ER Williams, M Wilm… - Nature Reviews Methods …, 2023 - nature.com
Applying a high voltage to a liquid passing through a capillary disintegrates the liquid
meniscus to generate a fine spray of charged droplets. As the droplets evaporate, polar …

[HTML][HTML] Towards a comprehensive characterisation of the human internal chemical exposome: Challenges and perspectives

A David, J Chaker, EJ Price, V Bessonneau… - Environment …, 2021 - Elsevier
The holistic characterisation of the human internal chemical exposome using high-resolution
mass spectrometry (HRMS) would be a step forward to investigate the environmental …

A critical analysis of electrospray techniques for the determination of accelerated rates and mechanisms of chemical reactions in droplets

G Rovelli, MI Jacobs, MD Willis, RJ Rapf… - Chemical …, 2020 - pubs.rsc.org
Electrospray and Electrosonic Spray Ionization Mass Spectrometry (ESI-MS and ESSI-MS)
have been widely used to report evidence that many chemical reactions in micro-and nano …

A review of nanoscale LC-ESI for metabolomics and its potential to enhance the metabolome coverage

AJ Chetwynd, A David - Talanta, 2018 - Elsevier
Liquid chromatography-electrospray ionisation-mass spectrometry (LC-ESI-MS) platforms
are widely used to perform high throughput untargeted profiling of biological samples for …

Neutral particle mass spectrometry with nanomechanical systems

E Sage, A Brenac, T Alava, R Morel, C Dupré… - Nature …, 2015 - nature.com
Current approaches to mass spectrometry (MS) require ionization of the analytes of interest.
For high-mass species, the resulting charge state distribution can be complex and difficult to …

Low-flow sheathless capillary electrophoresis–mass spectrometry for sensitive glycoform profiling of intact pharmaceutical proteins

R Haselberg, GJ de Jong, GW Somsen - Analytical chemistry, 2013 - ACS Publications
Capillary electrophoresis coupled to time-of-flight mass spectrometry (CE–TOF-MS) via a
porous tip sheathless electrospray ionization (ESI) interface was studied for the …

Nanoelectrospray emitters: trends and perspective

GTT Gibson, SM Mugo… - Mass Spectrometry …, 2009 - Wiley Online Library
The benefits of electrospray ionization are many, including sensitivity, robustness, simplicity
and the ability to couple continuous flow methods with mass spectrometry. The technique …

Improving the comprehensiveness and sensitivity of sheathless capillary electrophoresis–tandem mass spectrometry for proteomic analysis

Y Wang, BR Fonslow, CCL Wong… - Analytical …, 2012 - ACS Publications
We describe a solid phase microextraction (SPME), multistep elution, transient
isotachophoresis (tITP) capillary electrophoresis–tandem mass spectrometry (CE–MS/MS) …

Capillary electrophoresis–electrospray ionization-mass spectrometry interfaces: Fundamental concepts and technical developments

G Bonvin, J Schappler, S Rudaz - Journal of Chromatography A, 2012 - Elsevier
Capillary electrophoresis (CE) hyphenated to electrospray ionization (ESI) mass
spectrometry (MS) is a powerful tool for analyzing a wide variety of analytes in different …

Improved electrospray ionization efficiency compensates for diminished chromatographic resolution and enables proteomics analysis of tyrosine signaling in …

SB Ficarro, Y Zhang, Y Lu, AR Moghimi… - Analytical …, 2009 - ACS Publications
Characterization of signaling pathways in embryonic stem cells is a prerequisite for future
application of these cells to treat human disease and other disorders. Identification of …