Malignant tumor cells display uncontrolled proliferation, loss of epithelial cell polarity, altered
interactions with neighboring cells and the surrounding extracellular matrix, and enhanced …

Rac is a member of the Rho family of small GTPases, which act as molecular switches to
control a wide array of cellular functions. In particular, Rac signaling has been implicated in …

X-linked lymphoproliferative disease (XLP) is a rare congenital immunodeficiency that leads
to an extreme, usually fatal increase in the number of lymphocytes upon infection with EBV …

Malignant melanoma claims more lives than any other skin malignancy. While primary
melanomas are usually cured via surgical excision, the metastatic form of the disease …

Caspase-8 (casp8) is required for extrinsic apoptosis, and mice deficient in casp8 fail to
develop and die in utero while ultimately failing to maintain the proliferation of T cells, B …

Recent studies have revealed the critical role of programmed death-1 (PD-1) in exhaustion
of HIV-and SIV-specific CD8+ T cells. In this study, we show that high expression of PD-1 …

RhoGEFs (guanine nucleotide exchange factors of the Rho GTPase family) are upstream
regulators of cell adhesion and migration pathways, thus representing attractive yet …

The family of tumor necrosis factor receptors (TNFRs) and their ligands form a regulatory
signaling network that controls immune responses. Various members of this receptor family …

Azathioprine and 6-mercaptopurine remain pivotal therapies for the maintenance of disease
remission in patients with Crohn's disease and ulcerative colitis. While thiopurine S …

Interactions between the TNF-family receptor Fas (CD95) and Fas Ligand (FasL, CD178)
can efficiently induce apoptosis and are critical for the maintenance of immunological self …