Sleep as a window of cardiometabolic health: The potential of digital sleep and circadian biomarkers

WJ van den Brink, JE Oosterman, DJ Smid… - DIGITAL …, 2025 - journals.sagepub.com
Digital biomarkers are quantifiable and objective indicators of a person's physiological
function, behavioral state or treatment response, that can be captured using connected …

Binge drinking and progression of white matter hyperintensities of presumed vascular origin in older men

OH Del Brutto, DA Rumbea, RM Mera - Journal of Stroke and …, 2024 - Elsevier
Background Information on trajectories of diffuse subcortical brain damage of vascular origin
associated with binge drinking in older adults is limited. We sought to evaluate the impact of …

Implication of heart rate variability on cerebral small vessel disease: a potential therapeutic target

Y Tian, D Yao, Y Pan, M Wang, X Meng… - CNS neuroscience & …, 2023 - Wiley Online Library
Objective This study aimed to investigate the relationships of heart rate variability (HRV) with
the presence, severity, and individual neuroimaging markers of cerebral small vessel …

Patterns of progression of cerebral small vessel disease markers in older adults of Amerindian ancestry: a population-based, longitudinal prospective cohort study

OH Del Brutto, RM Mera, AF Costa, DA Rumbea… - Aging Clinical and …, 2022 - Springer
Background Progression of cerebral small vessel disease (cSVD) markers has been studied
in different races/ethnic groups. However, information from individuals of Amerindian …

Systemic immune-inflammation index and progression of white matter hyperintensities of presumed vascular origin. A longitudinal population study in community …

OH Del Brutto, RM Mera, DA Rumbea… - Journal of the …, 2023 - Elsevier
Background Information on the association between the systemic immune-inflammation
index (SII) and white matter hyperintensities (WMH) of presumed vascular origin is confined …

Arterial stiffness and progression of white matter hyperintensities of presumed vascular origin in community-dwelling older adults of Amerindian ancestry: The …

OH Del Brutto, RM Mera, AF Costa, BY Recalde… - Clinical Neurology and …, 2022 - Elsevier
Objective Arterial stiffness–as measured by the aortic pulse wave velocity (aPWV)–has been
associated with biomarkers of cerebral small vessel disease (cSVD), in particular with white …

White Matter Hyperintensities Severity And Progression Are Not Related To Earlobe Crease Presence. A Cross-Sectional And Longitudinal Prospective Study In …

AF Costa, RM Mera, DA Rumbea… - Revista Ecuatoriana …, 2023 - scielo.senescyt.gob.ec
Background: Earlobe crease (ELC) has been associated with coronary atherosclerosis.
Recently, ELC has been associated with white matter hyperintensities (WMH) of presumed …