The extracellular matrix (ECM) surrounds cells in the brain, providing structural and
functional support. Emerging studies demonstrate that the ECM plays important roles during …

A structural scaffold embedding brain cells and vasculature is known as extracellular matrix
(ECM). The physical appearance of ECM in the central nervous system (CNS) ranges from a …

Microglia are the tissue-resident macrophage population of the brain, specialized in
supporting the CNS environment and protecting it from endogenous and exogenous insults …

Neurodegenerative diseases (NDDs) affect more than 50 million people worldwide, posing
a significant global health challenge as well as a high socioeconomic burden. With aging …

Tissue-resident macrophages of the brain, including microglia, are implicated in the
pathogenesis of various CNS disorders and are possible therapeutic targets by their …

The hypothalamus plays a crucial role in controlling metabolism and energy balance, with
Agouti-related protein (AgRP) neurons and proopiomelanocortin (POMC) neurons being …

Schizophrenia is a grave neuropsychiatric disease which frequently onsets between the end
of adolescence and the beginning of adulthood. It is characterized by a variety of …

Cerebral ischemia is a devastating condition that results in impaired blood flow in the brain
leading to acute brain injury. As the most common form of stroke, occlusion of cerebral …

The brain requires large quantities of energy to sustain its functions. At the same time, the
brain is isolated from the rest of the body, forcing this organ to develop strategies to control …

Microglia are subject to change in tandem with the endogenously generated biological
oscillations known as our circadian rhythm. Studies have shown microglia harbor an intrinsic …