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It's not a bug, it's a feature: functional materials in insects
Over the course of their wildly successful proliferation across the earth, the insects as a
taxon have evolved enviable adaptations to their diverse habitats, which include adhesives …
taxon have evolved enviable adaptations to their diverse habitats, which include adhesives …
Nanopore‐Based, Rapid Characterization of Individual Amyloid Particles in Solution: Concepts, Challenges, and Prospects
Aggregates of misfolded proteins are associated with several devastating
neurodegenerative diseases. These so‐called amyloids are therefore explored as …
neurodegenerative diseases. These so‐called amyloids are therefore explored as …
How do the properties of amphiphilic polymer membranes influence the functional insertion of peptide pores?
Pore-forming peptides are of high biological relevance particularly as cytotoxic agents, but
their properties are also applicable for the permeabilization of lipid membranes for …
their properties are also applicable for the permeabilization of lipid membranes for …
Characterisation of cell membrane interaction mechanisms of antimicrobial peptides by electrical bilayer recording
Many antimicrobial peptides (AMPs) are cationic host defence peptides (HDPs) that interact
with microbial membranes. This ability may lead to implementation of AMPs as therapeutics …
with microbial membranes. This ability may lead to implementation of AMPs as therapeutics …
Effects of peptide charge, orientation, and concentration on melittin transmembrane pores
Melittin is a short cationic peptide that exerts cytolytic effects on bacterial and eukaryotic
cells. Experiments suggest that in zwitterionic membranes, melittin forms transmembrane …
cells. Experiments suggest that in zwitterionic membranes, melittin forms transmembrane …
Tuning the diameter, stability, and membrane affinity of peptide pores by DNA-programmed self-assembly
Protein pores recently enabled a breakthrough in bioanalytics by making it possible to
sequence individual DNA and RNA strands during their translocation through the lumen of …
sequence individual DNA and RNA strands during their translocation through the lumen of …
[HTML][HTML] Mechanistic Insight into the Early Stages of Toroidal Pore Formation by the Antimicrobial Peptide Smp24
The antimicrobial peptide Smp24, originally derived from the venom of Scorpio maurus
palmatus, is a promising candidate for further drug development. However, before doing so …
palmatus, is a promising candidate for further drug development. However, before doing so …
Conformations and dynamic transitions of a melittin derivative that forms macromolecule-sized pores in lipid bilayers
Systematically evolved from the primary active component of bee venom, MelP5 is a
lipophilic peptide with important physical properties that differ from wild-type melittin …
lipophilic peptide with important physical properties that differ from wild-type melittin …
Lipid-Centric Approaches in Combating Infectious Diseases: Antibacterials, Antifungals and Antivirals with Lipid-Associated Mechanisms of Action
One of the global challenges of the 21st century is the increase in mortality from infectious
diseases against the backdrop of the spread of antibiotic-resistant pathogenic …
diseases against the backdrop of the spread of antibiotic-resistant pathogenic …
Residue-specialized membrane poration kinetics of melittin and its variants: insight from mechanistic landscapes
Pore-forming peptides have promising potentials for biomedical uses due to their ability to
permeabilize cell membranes. However, to molecularly engineer them for practical …
permeabilize cell membranes. However, to molecularly engineer them for practical …