Spirocyclic scaffolds are incorporated in various approved drugs and drug candidates. The
increasing interest in less planar bioactive compounds has given rise to the development of …

In order to optimize a lead molecule for further development, bioisosteric replacements are
generally adopted as one of the strategies. Silicon appears to be the right choice as a …

This review aims to highlight the role of silicon in drug discovery. Silicon and carbon are
often regarded as being similar with silicon located directly beneath carbon in the same …

Application of silyl functionalities is one of the most promising strategies among various
'elements chemistry'approaches for the development of novel and distinctive drug …

Construction of Benzosiloles, Six- and Eight-Membered Silacyclic Skeletons, via a Pd-Catalyzed
Intramolecular Mizoroki–Heck Reaction of Vinylsilanes | Organic Letters ACS ACS Publications …

Silaazacycles (or azasilacycles), containing both nitrogen and silicon atoms, are appealing
ring structures in the development of silicon-containing functional molecules. The …

A catalytic intramolecular silapalladation of alkynes affords, in good yields and
stereoselectively, syn‐disilylated heterocycles of different chemical structure and size. When …

Abstract Loperamide (1a), an opioid receptor agonist, is in clinical use as an antidiarrheal
agent. Carbon/silicon exchange (sila‐substitution) at the 4‐position of the piperidine ring of …

Silicon chemistry offers the potential to tune the effects of biologically active organic
molecules. Subtle changes in the molecular backbone caused by the exchange of a carbon …

Silicon chemistry has been demonstrated to be a novel source of chemical diversity in drug
design. The carbon/silicon switch strategy, ie, the strategic replacement of a carbon atom …