The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling
pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular …

Hypoxia, a common feature of the tumor microenvironment in various types of cancers,
weakens cytotoxic T cell function and causes recruitment of regulatory T cells, thereby …

Cellular iron, at the physiological level, is essential to maintain several metabolic pathways,
while an excess of free iron may cause oxidative damage and/or provoke cell death …

The c-Jun N-terminal kinases (JNKs), with its members JNK1, JNK2, and JNK3, is a
subfamily of (MAPK) mitogen-activated protein kinases. JNK signaling regulates a wide …

Receptor tyrosine kinases (RTKs) are transmembrane cell-surface proteins that act as signal
transducers. They regulate essential cellular processes like proliferation, apoptosis …

The metastasis of cancer cells is the main cause of death in patients with gastric cancer
(GC). Mounting evidence has demonstrated the vital importance of tumor-associated …

Background: It is estimated that one in five people worldwide faces a diagnosis of a
malignant neoplasm during their lifetime. Carvacrol and its isomer, thymol, are natural …

Abstract c-Jun N-terminal kinase (JNK) signalling regulates both cancer cell apoptosis and
survival. Emerging evidence show that JNK promoted tumour progression is involved in …

Nowadays, melatonin, previously considered only as a pharmaceutical product for rhythm
regulation and sleep aiding, has shown its potential as a co‐adjuvant treatment in intestinal …

Mitogen‐activated protein kinase (MAPK) activation by natural compounds is known to be
involved in the induction of apoptosis, paraptosis, and autophagy. Cannabidiol (CBD), a …