Most metastatic cancers remain incurable due to the emergence of apoptosis-resistant
clones, fuelled by intratumour heterogeneity and tumour evolution. To improve treatment …

The process of dead cell clearance by phagocytic cells, called efferocytosis, prevents
inflammatory cell necrosis and promotes resolution and repair. Defective efferocytosis …

By replacing and removing defective or infected cells, programmed cell death (PCD)
contributes to homeostasis maintenance and body development, which is ubiquitously …

Necroptosis, a programmed cell death mechanism distinct from apoptosis, has garnered
attention for its role in various pathological conditions. While initially recognized for its …

Drug resistance in cancer remains a major challenge in oncology, impeding the
effectiveness of various treatment modalities. The nuclear factor-kappa B (NF-κB) signaling …

Hepatocellular Carcinoma (HCC), the most common primary liver cancer, ranks as the third
most common cause of cancer-related deaths globally. A deeper understanding of the cell …

The liver is a vital organ that continuously adapts to a wide and dynamic diversity of self-
antigens and xenobiotics. This involves the active contribution of immune cells, particularly …

Perfluoroalkyl and polyfluoroalkyl substances (PFASs) are synthetic chemicals,
encompassing compounds like perfluorooctane sulfonate (PFOS), which have widespread …

Necroptosis is a lytic form of regulated cell death reported to contribute to inflammatory
diseases of the gut, skin and lung, as well as ischemic-reperfusion injuries of the kidney …

Immune and tissue homeostasis is achieved through balancing signals that regulate cell
survival, proliferation, and cell death. Recent studies indicate that certain cell death …