Ten years after the initial generation of induced pluripotent stem cells (hiPSCs) from human
tissues, their potential is no longer questioned, with over 15000 publications listed on …

Although human embryonic stem cells (hESCs) were first derived almost 20 years ago, it
was only recently acknowledged that they share closer molecular and functional identity to …

Down syndrome (DS) or trisomy 21 (T21) is a leading genetic cause of intellectual disability.
To gain insights into dynamics of molecular perturbations during neurogenesis in DS, we …

Dravet syndrome (DS) is a devastating early-onset refractory epilepsy syndrome caused by
variants in the SCN1A gene. A disturbed GABAergic interneuron function is implicated in the …

Dravet syndrome (DRVT) is a rare form of neurodevelopmental disorder with a high risk of
sudden unexpected death in epilepsy (SUDEP), caused mainly (> 80% cases) by mutations …

Cardiovascular disease (CVD) is one of the contributing factors to more than one-third of
human mortality and the leading cause of death worldwide. The death of cardiac myocyte is …

Different hepatoxic factors cause irreversible liver injury, leading to liver failure, cirrhosis,
and cancer in mammals. Liver transplantation is the only effective strategy, which can …

Inherited retinal degeneration is a term used to describe heritable disorders that result from
the death of light sensing photoreceptor cells. Although we and others believe that it will be …

Nijmegen Breakage Syndrome (NBS) is a rare autosomal recessive genetic disorder caused
by mutations within nibrin (NBN), a DNA damage repair protein. Hallmarks of NBS include …

Mowat-Wilson syndrome (MWS) is a severe neurodevelopmental disorder caused by
heterozygous variants in the gene encoding transcription factor ZEB2. Affected individuals …