Schizophrenia is a complex neuropsychiatric syndrome with a heterogeneous genetic,
neurobiological, and phenotypic profile. Currently, no objective biological measures—that is …

The incidence of neurodegenerative diseases has shown an increasing trend. These
conditions typically cause progressive functional disability. Identification of robust …

The heterogeneity of schizophrenia has defied efforts to derive reproducible and definitive
anatomical maps of structural brain changes associated with the disorder. We aimed to map …

Psychiatric disorders are often distinguished from neurological disorders in that the former
do not have characteristic lesions or findings from cerebrospinal fluid …

There has been an increasing prevalence of neurodegenerative diseases with the rapid
increase in aging societies worldwide. Biomarkers that can be used to detect pathological …

White-matter abnormalities, including increases in extracellular free-water, are implicated in
the pathophysiology of schizophrenia. Recent advances in diffusion magnetic resonance …

Abstract Studies applying Free Water Imaging have consistently reported significant global
increases in extracellular free water (FW) in populations of individuals with early psychosis …

Understanding the neuropathological underpinnings of mental disorders such as
schizophrenia, major depression, and bipolar disorder is an essential step towards the …

Brain iron is central to dopaminergic neurotransmission, a key component in schizophrenia
pathology. Iron can also generate oxidative stress, which is one proposed mechanism for …

Accumulating evidence suggests that inflammation is not limited to archetypal inflammatory
diseases such as multiple sclerosis, but instead represents an intrinsic feature of many …